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Science 20 April 2007:
Vol. 316. no. 5823, pp. 409 - 410
DOI: 10.1126/science.1138772
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Review

Gametes from Embryonic Stem Cells: A Cup Half Empty or Half Full?

George Q. Daley

When first reported 4 years ago, gametogenesis from embryonic stem (ES) cells promised an accessible in vitro model to facilitate molecular analysis of the germ lineage. Formation of primordial germ cells is robust, but terminal gametogenesis remains inefficient and doubts about gamete function persist. Although useful for research, clinical use of ES cell–derived gametes appears a distant prospect.

Division of Pediatric Hematology/Oncology, Children's Hospital Boston; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School; Division of Hematology, Brigham and Women's Hospital, Boston, MA; Harvard Stem Cell Institute, Cambridge, MA, USA.

E-mail: george.daley{at}childrens.harvard.edu.

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Heritable Imprinting Defect Caused by Epigenetic Abnormalities in Mouse Spermatogonial Stem Cells.
J. Lee, M. Kanatsu-Shinohara, N. Ogonuki, H. Miki, K. Inoue, T. Morimoto, H. Morimoto, A. Ogura, and T. Shinohara (2009)
Biol Reprod 80, 518-527
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Animal models for fertility preservation in the male.
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A comprehensive, non-invasive visualization of primordial germ cell development in mice by the Prdm1-mVenus and Dppa3-ECFP double transgenic reporter.
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Preservation of Fertility in Pediatric and Adolescent Patients With Cancer.
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The origin of human aneuploidy: where we have been, where we are going.
T. Hassold, H. Hall, and P. Hunt (2007)
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Science. ISSN 0036-8075 (print), 1095-9203 (online)