Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 20 April 2007:
Vol. 316. no. 5823, pp. 402 - 404
DOI: 10.1126/science.1140861
Prev | Table of Contents | Next

Review

Male and Female Drosophila Germline Stem Cells: Two Versions of Immortality

Margaret T. Fuller1 and Allan C. Spradling2

Drosophila male and female germline stem cells (GSCs) are sustained by niches and regulatory pathways whose common principles serve as models for understanding mammalian stem cells. Despite striking cellular and genetic similarities that suggest a common evolutionary origin, however, male and female GSCs also display important differences. Comparing these two stem cells and their niches in detail is likely to reveal how a common heritage has been adapted to the differing requirements of male and female gamete production.

1 Departments of Developmental Biology and Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
2 Department of Embryology and Howard Hughes Medical Institute (HHMI), Carnegie Institution of Washington, Baltimore, MD 21218, USA.

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Chromatin and the cell cycle meet in Madrid.
M. Dominguez and F. Berger (2008)
Development 135, 3475-3480
   Abstract »    Full Text »    PDF »
Drosophila optic lobe neuroblasts triggered by a wave of proneural gene expression that is negatively regulated by JAK/STAT.
T. Yasugi, D. Umetsu, S. Murakami, M. Sato, and T. Tabata (2008)
Development 135, 1471-1480
   Abstract »    Full Text »    PDF »
The JAK/STAT pathway positively regulates DPP signaling in the Drosophila germline stem cell niche.
L. Wang, Z. Li, and Y. Cai (2008)
J. Cell Biol. 180, 721-728
   Abstract »    Full Text »    PDF »
Skin stem cells: rising to the surface.
E. Fuchs (2008)
J. Cell Biol. 180, 273-284
   Abstract »    Full Text »    PDF »
The hematopoietic stem cell and its niche: a comparative view.
J. A. Martinez-Agosto, H. K.A. Mikkola, V. Hartenstein, and U. Banerjee (2007)
Genes & Dev. 21, 3044-3060
   Abstract »    Full Text »    PDF »


ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)