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Science 20 April 2007:
Vol. 316. no. 5823, p. 397
DOI: 10.1126/science.1137543
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Review

piRNAs in the Germ Line

Haifan Lin

Small noncoding RNAs have emerged as potent regulators of gene expression at both transcriptional and posttranscriptional levels. Recently, a class of small RNAs that interact with Piwi proteins has been discovered in the mammalian germ line and Drosophila. These Piwi-interacting RNAs (piRNAs) represent a distinct small RNA pathway.

Yale Stem Cell Center, Yale University School of Medicine, New Haven, CT 06510, USA.

E-mail: haifan.lin{at}yale.edu

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Mice Deficient for a Small Cluster of Piwi-Interacting RNAs Implicate Piwi-Interacting RNAs in Transposon Control.
M. Xu, Y. You, P. Hunsicker, T. Hori, C. Small, M. D Griswold, and N. B Hecht (2008)
Biol Reprod 79, 51-57
   Abstract »    Full Text »    PDF »
MicroRNA: basic mechanisms and transcriptional regulatory networks for cell fate determination.
F. Fazi and C. Nervi (2008)
Cardiovasc Res
   Abstract »    Full Text »    PDF »
The PIWI proteins SMEDWI-2 and SMEDWI-3 are required for stem cell function and piRNA expression in planarians.
D. Palakodeti, M. Smielewska, Y.-C. Lu, G. W. Yeo, and B. R. Graveley (2008)
RNA 14, 1174-1186
   Abstract »    Full Text »    PDF »
aubergine Gene Overexpression in Somatic Tissues of auberginesting Mutants Interferes With the RNAi Pathway of a yellow Hairpin dsRNA in Drosophila melanogaster.
V. Specchia, C. Benna, G. M. Mazzotta, A. Piccin, M. A. Zordan, R. Costa, and M. P. Bozzetti (2008)
Genetics 178, 1271-1282
   Abstract »    Full Text »    PDF »
The Caenorhabditis elegans ekl (Enhancer of ksr-1 Lethality) Genes Include Putative Components of a Germline Small RNA Pathway.
C. E. Rocheleau, K. Cullison, K. Huang, Y. Bernstein, A. C. Spilker, and M. V. Sundaram (2008)
Genetics 178, 1431-1443
   Abstract »    Full Text »    PDF »
piRNABank: a web resource on classified and clustered Piwi-interacting RNAs.
S. Sai Lakshmi and S. Agrawal (2008)
Nucleic Acids Res. 36, D173-D177
   Abstract »    Full Text »    PDF »
Cloning and expression profiling of small RNAs expressed in the mouse ovary.
S. Ro, R. Song, C. Park, H. Zheng, K. M. Sanders, and W. Yan (2007)
RNA 13, 2366-2380
   Abstract »    Full Text »    PDF »
Concise Review: Roles of Polycomb Group Proteins in Development and Disease: A Stem Cell Perspective.
V. K. Rajasekhar and M. Begemann (2007)
Stem Cells 25, 2498-2510
   Abstract »    Full Text »    PDF »
Drosophila PIWI associates with chromatin and interacts directly with HP1a.
B. Brower-Toland, S. D. Findley, L. Jiang, L. Liu, H. Yin, M. Dus, P. Zhou, S. C.R. Elgin, and H. Lin (2007)
Genes & Dev. 21, 2300-2311
   Abstract »    Full Text »    PDF »
Epigenetic Decisions in Mammalian Germ Cells.
C. B. Schaefer, S. K. T. Ooi, T. H. Bestor, and D. Bourc'his (2007)
Science 316, 398-399
   Abstract »    Full Text »    PDF »
Male Germline Stem Cells: From Mice to Men.
R. L. Brinster (2007)
Science 316, 404-405
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)