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Science 13 April 2007:
Vol. 316. no. 5822, pp. 243 - 246
DOI: 10.1126/science.1140615
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Reports

Evolutionary Formation of New Centromeres in Macaque

Mario Ventura,1* Francesca Antonacci,1* Maria Francesca Cardone,1 Roscoe Stanyon,2 Pietro D'Addabbo,1 Angelo Cellamare,1 L. James Sprague,3 Evan E. Eichler,3 Nicoletta Archidiacono,1 Mariano Rocchi1{dagger}

A systematic fluorescence in situ hybridization comparison of macaque and human synteny organization disclosed five additional macaque evolutionary new centromeres (ENCs) for a total of nine ENCs. To understand the dynamics of ENC formation and progression, we compared the ENC of macaque chromosome 4 with the human orthologous region, at 6q24.3, that conserves the ancestral genomic organization. A 250-kilobase segment was extensively duplicated around the macaque centromere. These duplications were strictly intrachromosomal. Our results suggest that novel centromeres may trigger only local duplication activity and that the absence of genes in the seeding region may have been important in ENC maintenance and progression.

1 Department of Genetics and Microbiology, University of Bari, 70126 Bari, Italy.
2 Department of Animal Biology and Genetics, University of Florence, Florence 50125, Italy.
3 Howard Hughes Medical Institute, Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA.

* These authors contributed equally to this work.

{dagger} To whom correspondence should be addressed. E-mail: rocchi{at}biologia.uniba.it

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