Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 23 March 2007:
Vol. 315. no. 5819, pp. 1719 - 1722
DOI: 10.1126/science.1139207
Prev | Table of Contents | Next

Reports

Temporal Frequency of Subthreshold Oscillations Scales with Entorhinal Grid Cell Field Spacing

Lisa M. Giocomo,1* Eric A. Zilli,1 Erik Fransén,2 Michael E. Hasselmo1*

Grid cells in layer II of rat entorhinal cortex fire to spatial locations in a repeating hexagonal grid, with smaller spacing between grid fields for neurons inmore dorsal anatomical locations. Data from in vitro whole-cell patch recordings showed differences in frequency of subthreshold membrane potential oscillations in entorhinal neurons that correspond to different positions along the dorsal-to-ventral axis, supporting a model of physiological mechanisms for grid cell responses.

1 Center for Memory and Brain, Department of Psychology, Program in Neuroscience, Boston University, 2 Cummington Street, Boston, MA 02215, USA.
2 School of Computer Science and Communication, Royal Institute of Technology and Stockholm Brain Institute, SE-100 44 Stockholm, Sweden.

* To whom correspondence should be addressed. E-mail: hasselmo{at}bu.edu (M.E.H.); giocomo{at}bu.edu (L.M.G.)

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Complementary Theta Resonance Filtering by Two Spatially Segregated Mechanisms in CA1 Hippocampal Pyramidal Neurons.
H. Hu, K. Vervaeke, L. J. Graham, and J. F. Storm (2009)
J. Neurosci. 29, 14472-14483
   Abstract »    Full Text »    PDF »
Knock-Out of HCN1 Subunit Flattens Dorsal-Ventral Frequency Gradient of Medial Entorhinal Neurons in Adult Mice.
L. M. Giocomo and M. E. Hasselmo (2009)
J. Neurosci. 29, 7625-7630
   Abstract »    Full Text »    PDF »
Membrane Resonance in Bursting Pacemaker Neurons of an Oscillatory Network Is Correlated with Network Frequency.
V. Tohidi and F. Nadim (2009)
J. Neurosci. 29, 6427-6435
   Abstract »    Full Text »    PDF »
Reduction of Spike Afterdepolarization by Increased Leak Conductance Alters Interspike Interval Variability.
F. R. Fernandez and J. A. White (2009)
J. Neurosci. 29, 973-986
   Abstract »    Full Text »    PDF »
Development of Theta Rhythmicity in Entorhinal Stellate Cells of the Juvenile Rat.
B. G. Burton, M. N. Economo, G. J. Lee, and J. A. White (2008)
J Neurophysiol 100, 3144-3157
   Abstract »    Full Text »    PDF »
Time Constants of h Current in Layer II Stellate Cells Differ along the Dorsal to Ventral Axis of Medial Entorhinal Cortex.
L. M. Giocomo and M. E. Hasselmo (2008)
J. Neurosci. 28, 9414-9425
   Abstract »    Full Text »    PDF »
Subthreshold Membrane-Potential Resonances Shape Spike-Train Patterns in the Entorhinal Cortex.
T. A. Engel, L. Schimansky-Geier, A.V.M. Herz, S. Schreiber, and I. Erchova (2008)
J Neurophysiol 100, 1576-1589
   Abstract »    Full Text »    PDF »
The h Channel Mediates Location Dependence and Plasticity of Intrinsic Phase Response in Rat Hippocampal Neurons.
R. Narayanan and D. Johnston (2008)
J. Neurosci. 28, 5846-5860
   Abstract »    Full Text »    PDF »
Artificial Synaptic Conductances Reduce Subthreshold Oscillations and Periodic Firing in Stellate Cells of the Entorhinal Cortex.
F. R. Fernandez and J. A. White (2008)
J. Neurosci. 28, 3790-3803
   Abstract »    Full Text »    PDF »
Arc length coding by interference of theta frequency oscillations may underlie context-dependent hippocampal unit data and episodic memory function.
M. E. Hasselmo (2007)
Learn. Mem. 14, 782-794
   Abstract »    Full Text »    PDF »
HCN1 Channels Control Resting and Active Integrative Properties of Stellate Cells from Layer II of the Entorhinal Cortex.
M. F. Nolan, J. T. Dudman, P. D. Dodson, and B. Santoro (2007)
J. Neurosci. 27, 12440-12451
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)