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Science 23 March 2007:
Vol. 315. no. 5819, pp. 1719 - 1722
DOI: 10.1126/science.1139207
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Reports

Temporal Frequency of Subthreshold Oscillations Scales with Entorhinal Grid Cell Field Spacing

Lisa M. Giocomo,1* Eric A. Zilli,1 Erik Fransén,2 Michael E. Hasselmo1*

Grid cells in layer II of rat entorhinal cortex fire to spatial locations in a repeating hexagonal grid, with smaller spacing between grid fields for neurons inmore dorsal anatomical locations. Data from in vitro whole-cell patch recordings showed differences in frequency of subthreshold membrane potential oscillations in entorhinal neurons that correspond to different positions along the dorsal-to-ventral axis, supporting a model of physiological mechanisms for grid cell responses.

1 Center for Memory and Brain, Department of Psychology, Program in Neuroscience, Boston University, 2 Cummington Street, Boston, MA 02215, USA.
2 School of Computer Science and Communication, Royal Institute of Technology and Stockholm Brain Institute, SE-100 44 Stockholm, Sweden.

* To whom correspondence should be addressed. E-mail: hasselmo{at}bu.edu (M.E.H.); giocomo{at}bu.edu (L.M.G.)

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Science. ISSN 0036-8075 (print), 1095-9203 (online)