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Science 23 March 2007:
Vol. 315. no. 5819, pp. 1719 - 1722
DOI: 10.1126/science.1139207
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Reports

Temporal Frequency of Subthreshold Oscillations Scales with Entorhinal Grid Cell Field Spacing

Lisa M. Giocomo,1* Eric A. Zilli,1 Erik Fransén,2 Michael E. Hasselmo1*

Grid cells in layer II of rat entorhinal cortex fire to spatial locations in a repeating hexagonal grid, with smaller spacing between grid fields for neurons inmore dorsal anatomical locations. Data from in vitro whole-cell patch recordings showed differences in frequency of subthreshold membrane potential oscillations in entorhinal neurons that correspond to different positions along the dorsal-to-ventral axis, supporting a model of physiological mechanisms for grid cell responses.

1 Center for Memory and Brain, Department of Psychology, Program in Neuroscience, Boston University, 2 Cummington Street, Boston, MA 02215, USA.
2 School of Computer Science and Communication, Royal Institute of Technology and Stockholm Brain Institute, SE-100 44 Stockholm, Sweden.

* To whom correspondence should be addressed. E-mail: hasselmo{at}bu.edu (M.E.H.); giocomo{at}bu.edu (L.M.G.)

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Artificial Synaptic Conductances Reduce Subthreshold Oscillations and Periodic Firing in Stellate Cells of the Entorhinal Cortex.
F. R. Fernandez and J. A. White (2008)
J. Neurosci. 28, 3790-3803
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Arc length coding by interference of theta frequency oscillations may underlie context-dependent hippocampal unit data and episodic memory function.
M. E. Hasselmo (2007)
Learn. Mem. 14, 782-794
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HCN1 Channels Control Resting and Active Integrative Properties of Stellate Cells from Layer II of the Entorhinal Cortex.
M. F. Nolan, J. T. Dudman, P. D. Dodson, and B. Santoro (2007)
J. Neurosci. 27, 12440-12451
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