Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Asymmetric T Lymphocyte Division in the Initiation of Adaptive Immune Responses
John T. Chang,1*Vikram R. Palanivel,1*Ichiko Kinjyo,1Felix Schambach,1Andrew M. Intlekofer,1Arnob Banerjee,1Sarah A. Longworth,1Kristine E. Vinup,1Paul Mrass,2Jane Oliaro,3Nigel Killeen,4Jordan S. Orange,5Sarah M. Russell,3,6Wolfgang Weninger,2Steven L. Reiner1
A hallmark of mammalian immunity is the heterogeneity of cellfate that exists among pathogen-experienced lymphocytes. Weshow that a dividing T lymphocyte initially responding to amicrobe exhibits unequal partitioning of proteins that mediatesignaling, cell fate specification, and asymmetric cell division.Asymmetric segregation of determinants appears to be coordinatedby prolonged interaction between the T cell and its antigen-presentingcell before division. Additionally, the first two daughter Tcells displayed phenotypic and functional indicators of beingdifferentially fated toward effector and memory lineages. Theseresults suggest a mechanism by which a single lymphocyte canapportion diverse cell fates necessary for adaptive immunity.
1 Abramson Family Cancer Research Institute and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. 2 Immunology Program, The Wistar Institute, Philadelphia, PA 19104, USA. 3 Immune Signalling Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria 2002, Australia. 4 Department of Microbiology and Immunology, University of California, San Francisco, CA 94143, USA. 5 Department of Pediatrics, University of Pennsylvania, Philadelphia, PA 19104, USA. 6 Center for MicroPhotonics, Faculty of Engineering and Industrial Sciences, Swinburne University of Technology, Victoria 3122, Australia.
* These authors contributed equally to this work.
To whom correspondence should be addressed. E-mail: sreiner{at}mail.med.upenn.edu
Functional and genomic profiling of effector CD8 T cell subsets with distinct memory fates.
S. Sarkar, V. Kalia, W. N. Haining, B. T. Konieczny, S. Subramaniam, and R. Ahmed (2008)
J. Exp. Med.
205, 625-640
|Abstract »|Full Text »|PDF »
Chronic CD4+ T-Cell Activation and Depletion in Human Immunodeficiency Virus Type 1 Infection: Type I Interferon-Mediated Disruption of T-Cell Dynamics.
A. R. Sedaghat, J. German, T. M. Teslovich, J. Cofrancesco Jr., C. C. Jie, C. C. Talbot Jr., and R. F. Siliciano (2008)
J. Virol.
82, 1870-1883
|Abstract »|Full Text »|PDF »
Effector CD8 T Cell Development: A Balancing Act between Memory Cell Potential and Terminal Differentiation.
Requirement for T-bet in the aberrant differentiation of unhelped memory CD8+ T cells.
A. M. Intlekofer, N. Takemoto, C. Kao, A. Banerjee, F. Schambach, J. K. Northrop, H. Shen, E. J. Wherry, and S. L. Reiner (2007)
J. Exp. Med.
204, 2015-2021
|Abstract »|Full Text »|PDF »
To whom correspondence should be addressed. E-mail: 
