Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
During development and tissue homeostasis, cells must integratedifferent signals. We investigated how cell behavior is controlledby the combined activity of transforming growth factor–ß(TGF-ß) and receptor tyrosine kinase (RTK) signaling,whose integration mechanism is unknown. We find that RTK/Ras/MAPK(mitogen-activated protein kinase) activity induces p53 N-terminalphosphorylation, enabling the interaction of p53 with the TGF-ß–activatedSmads. This mechanism confines mesoderm specification in Xenopusembryos and promotes TGF-ß cytostasis in human cells.These data indicate a mechanism to allow extracellular cuesto specify the TGF-ß gene-expression program.
Department of Medical Biotechnologies, Section of Histology and Embryology, University of Padua, Padua, Italy.
* To whom correspondence should be addressed. E-mail: piccolo{at}civ.bio.unipd.it
Anti-apoptotic and growth-stimulatory functions of CK1 delta and epsilon in ductal adenocarcinoma of the pancreas are inhibited by IC261 in vitro and in vivo.
C Brockschmidt, H Hirner, N Huber, T Eismann, A Hillenbrand, G Giamas, B Radunsky, O Ammerpohl, B Bohm, D Henne-Bruns, et al. (2008)
Gut
57, 799-806
|Abstract »|Full Text »|PDF »
Chromatin-Bound p53 Anchors Activated Smads and the mSin3A Corepressor To Confer Transforming Growth Factor {beta}-Mediated Transcription Repression.
D. S. Wilkinson, W.-W. Tsai, M. A. Schumacher, and M. C. Barton (2008)
Mol. Cell. Biol.
28, 1988-1998
|Abstract »|Full Text »|PDF »
Integration of Transforming Growth Factor {beta} and RAS Signaling Silences a RAB5 Guanine Nucleotide Exchange Factor and Enhances Growth Factor-Directed Cell Migration.
H. Hu, M. Milstein, J. M. Bliss, M. Thai, G. Malhotra, L. C. Huynh, and J. Colicelli (2008)
Mol. Cell. Biol.
28, 1573-1583
|Abstract »|Full Text »|PDF »
Activation of Bone Morphogenetic Protein Signaling by a Gemini Vitamin D3 Analogue Is Mediated by Ras/Protein Kinase C{alpha}.
H. J. Lee, Y. Ji, S. Paul, H. Maehr, M. Uskokovic, and N. Suh (2007)
Cancer Res.
67, 11840-11847
|Abstract »|Full Text »|PDF »
MAP-kinase activity necessary for TGFbeta1-stimulated mesangial cell type I collagen expression requires adhesion-dependent phosphorylation of FAK tyrosine 397.
T. Hayashida, M.-H. Wu, A. Pierce, A.-C. Poncelet, J. Varga, and H. W. Schnaper (2007)
J. Cell Sci.
120, 4230-4240
|Abstract »|Full Text »|PDF »
Mutant p53 Attenuates the SMAD-Dependent Transforming Growth Factor {beta}1 (TGF-{beta}1) Signaling Pathway by Repressing the Expression of TGF-{beta} Receptor Type II.
E. Kalo, Y. Buganim, K. E. Shapira, H. Besserglick, N. Goldfinger, L. Weisz, P. Stambolsky, Y. I. Henis, and V. Rotter (2007)
Mol. Cell. Biol.
27, 8228-8242
|Abstract »|Full Text »|PDF »
TGF{beta} superfamily signaling: notes from the desert.
