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Damage to the Insula Disrupts Addiction to Cigarette Smoking
Nasir H. Naqvi,1David Rudrauf,1,2Hanna Damasio,3,4Antoine Bechara1,3,4*
A number of brain systems have been implicated in addictivebehavior, but none have yet been shown to be necessary for maintainingthe addiction to cigarette smoking. We found that smokers withbrain damage involving the insula, a region implicated in consciousurges, were more likely than smokers with brain damage not involvingthe insula to undergo a disruption of smoking addiction, characterizedby the ability to quit smoking easily, immediately, withoutrelapse, and without persistence of the urge to smoke. Thisresult suggests that the insula is a critical neural substratein the addiction to smoking.
1 Division of Cognitive Neuroscience, Department of Neurology, University of Iowa Carver College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242, USA. 2 Laboratory of Computational Neuroimaging, Department of Neurology, University of Iowa Carver College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242, USA. 3 Dornsife Cognitive Neuroscience Imaging Center, SGM 501, University of Southern California, Los Angeles, CA 90089, USA. 4 Brain and Creativity Institute, HNB B26, University of Southern California, Los Angeles, CA 90089, USA.
* To whom correspondence should be addressed. E-mail: bechara{at}usc.edu
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LETTERS
Stanislav R. Vorel, Adam Bisaga, Guy McKhann, Herbert D. Kleber;, Nasir H. Naqvi, David Rudrauf, Hanna Damasio, and Antoine Bechara (20 July 2007) Science317 (5836), 318c.
[DOI: 10.1126/science.317.5836.318c] |Full Text »|PDF »
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