Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 26 January 2007:
Vol. 315. no. 5811, pp. 531 - 534
DOI: 10.1126/science.1135926
Prev | Table of Contents | Next

Reports

Damage to the Insula Disrupts Addiction to Cigarette Smoking

Nasir H. Naqvi,1 David Rudrauf,1,2 Hanna Damasio,3,4 Antoine Bechara1,3,4*

A number of brain systems have been implicated in addictive behavior, but none have yet been shown to be necessary for maintaining the addiction to cigarette smoking. We found that smokers with brain damage involving the insula, a region implicated in conscious urges, were more likely than smokers with brain damage not involving the insula to undergo a disruption of smoking addiction, characterized by the ability to quit smoking easily, immediately, without relapse, and without persistence of the urge to smoke. This result suggests that the insula is a critical neural substrate in the addiction to smoking.

1 Division of Cognitive Neuroscience, Department of Neurology, University of Iowa Carver College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242, USA.
2 Laboratory of Computational Neuroimaging, Department of Neurology, University of Iowa Carver College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242, USA.
3 Dornsife Cognitive Neuroscience Imaging Center, SGM 501, University of Southern California, Los Angeles, CA 90089, USA.
4 Brain and Creativity Institute, HNB B26, University of Southern California, Los Angeles, CA 90089, USA.

* To whom correspondence should be addressed. E-mail: bechara{at}usc.edu

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Disruption of Nicotine Addiction Associated With Paroxysmal Hypersomnia.
H. Sienkiewicz-Jarosz, P. Zatorski, A. Korkosz, D. Ryglewicz, L. Swiecicki, P. Bienkowski, and A. Scinska (2009)
J Neuropsychiatry Clin Neurosci 21, 342
   Full Text »    PDF »
Brain Regions Related to Tool Use and Action Knowledge Reflect Nicotine Dependence.
Y. Yalachkov, J. Kaiser, and M. J. Naumer (2009)
J. Neurosci. 29, 4922-4929
   Abstract »    Full Text »    PDF »
Nicotine activates TRPM5-dependent and independent taste pathways.
A. J. Oliveira-Maia, J. R. Stapleton-Kotloski, V. Lyall, T.-H. T. Phan, S. Mummalaneni, P. Melone, J. A. DeSimone, M. A. L. Nicolelis, and S. A. Simon (2009)
PNAS 106, 1596-1601
   Abstract »    Full Text »    PDF »
Parsing Pain Perception Between Nociceptive Representation and Magnitude Estimation.
M. N. Baliki, P. Y. Geha, and A. V. Apkarian (2009)
J Neurophysiol 101, 875-887
   Abstract »    Full Text »    PDF »
Treating Drug Abuse and Addiction in the Criminal Justice System: Improving Public Health and Safety.
R. K. Chandler, B. W. Fletcher, and N. D. Volkow (2009)
JAMA 301, 183-190
   Abstract »    Full Text »    PDF »
Involvement of Insula and Cingulate Cortices in Control and Suppression of Natural Urges.
A. Lerner, A. Bagic, T. Hanakawa, E. A. Boudreau, F. Pagan, Z. Mari, W. Bara-Jimenez, M. Aksu, S. Sato, D. L. Murphy, et al. (2009)
Cereb Cortex 19, 218-223
   Abstract »    Full Text »    PDF »
Neural Dissociation of Delay and Uncertainty in Intertemporal Choice.
C. C. Luhmann, M. M. Chun, D.-J. Yi, D. Lee, and X.-J. Wang (2008)
J. Neurosci. 28, 14459-14466
   Abstract »    Full Text »    PDF »
Insular hypocretin transmission regulates nicotine reward.
J. A. Hollander, Q. Lu, M. D. Cameron, T. M. Kamenecka, and P. J. Kenny (2008)
PNAS 105, 19480-19485
   Abstract »    Full Text »    PDF »
A critical role for the right fronto-insular cortex in switching between central-executive and default-mode networks.
D. Sridharan, D. J. Levitin, and V. Menon (2008)
PNAS 105, 12569-12574
   Abstract »    Full Text »    PDF »
Perspectives on Neuroscience and Behavior.
(2008)
Neuroscientist 14, 136-137
   PDF »
Neurokinin 1 Receptor Antagonism as a Possible Therapy for Alcoholism.
D. T. George, J. Gilman, J. Hersh, A. Thorsell, D. Herion, C. Geyer, X. Peng, W. Kielbasa, R. Rawlings, J. E. Brandt, et al. (2008)
Science 319, 1536-1539
   Abstract »    Full Text »    PDF »
Human Insula Activation Reflects Risk Prediction Errors As Well As Risk.
K. Preuschoff, S. R. Quartz, and P. Bossaerts (2008)
J. Neurosci. 28, 2745-2752
   Abstract »    Full Text »    PDF »
Acute Effect of Methadone Maintenance Dose on Brain fMRI Response to Heroin-Related Cues.
D. D. Langleben, K. Ruparel, I. Elman, S. Busch-Winokur, R. Pratiwadi, J. Loughead, C. P. O'Brien, and A. R. Childress (2008)
Am J Psychiatry 165, 390-394
   Abstract »    Full Text »    PDF »
Neural Substrates of Abstinence-Induced Cigarette Cravings in Chronic Smokers.
Z. Wang, M. Faith, F. Patterson, K. Tang, K. Kerrin, E. P. Wileyto, J. A. Detre, and C. Lerman (2007)
J. Neurosci. 27, 14035-14040
   Abstract »    Full Text »    PDF »
Profound Decreases in Dopamine Release in Striatum in Detoxified Alcoholics: Possible Orbitofrontal Involvement.
N. D. Volkow, G.-J. Wang, F. Telang, J. S. Fowler, J. Logan, M. Jayne, Y. Ma, K. Pradhan, and C. Wong (2007)
J. Neurosci. 27, 12700-12706
   Abstract »    Full Text »    PDF »
Inactivation of the Interoceptive Insula Disrupts Drug Craving and Malaise Induced by Lithium.
M. Contreras, F. Ceric, and F. Torrealba (2007)
Science 318, 655-658
   Abstract »    Full Text »    PDF »
Insula: Another Brain Region Important for Addiction.
(2007)
Journal Watch Psychiatry 2007, 4
   Full Text »
Bibliography for Substance Abuse: Diagnosis and Treatment.
(2007)
Focus 5, 184-186
   Full Text »    PDF »

E-Letters:

Read all E-Letters

A Strong Negative Attitude Against Smoking Is Associated with Insular Stroke
Jay R. Schrand
Science Online, 12 Apr 2007 [Full text]

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)