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Control of Drosophila Gastrulation by Apical Localization of Adherens Junctions and RhoGEF2
Verena Kölsch,1*Thomas Seher,1Gregorio J. Fernandez-Ballester,2Luis Serrano,3Maria Leptin1
A hallmark of epithelial invagination is the constriction ofcells on their apical sides. During Drosophila gastrulation,apical constrictions under the control of the transcriptionfactor Twist lead to the invagination of the mesoderm. Twist-controlledG protein signaling is involved in mediating the invaginationbut is not sufficient to account for the full activity of Twist.We identified a Twist target, the transmembrane protein T48,which acts in conjunction with G protein signaling to orchestrateshape changes. Together with G protein signaling, T48 recruitsadherens junctions and the cytoskeletal regulator RhoGEF2 tothe sites of apical constriction, ensuring rapid and intensechanges in cell shape.
1 Institute of Genetics, University of Cologne, Zülpicher Strasse 47, 50674 Cologne, Germany. 2 Instituto de Biología Molecular y Celular, Universidad Miguel Hernández, Edificio Torregaitán, Avenida de la Universidad, 03202 Elche, Spain. 3 European Molecular Biology Laboratory, Meyerhofstrasse 1, 69012 Heidelberg, Germany.
* Present address: Section of Cell and Developmental Biology,Division of Biological Sciences and Center for Molecular Genetics,University of California, San Diego, La Jolla, CA 92093, USA.
Present address: Centre de Regulació Genòmica,08003 Barcelona, Spain.
To whom correspondence should be addressed. E-mail: mleptin{at}uni-koeln.de
ADAN: a database for prediction of protein-protein interaction of modular domains mediated by linear motifs.
J. A. Encinar, G. Fernandez-Ballester, I. E. Sanchez, E. Hurtado-Gomez, F. Stricher, P. Beltrao, and L. Serrano (2009)
Bioinformatics
25, 2418-2424
|Abstract »|Full Text »|PDF »
Protein design in biological networks: from manipulating the input to modifying the output.
A. M. Van der Sloot, C. Kiel, L. Serrano, and F. Stricher (2009)
Protein Eng. Des. Sel.
22, 537-542
|Abstract »|Full Text »|PDF »
Dpp signaling promotes the cuboidal-to-columnar shape transition of Drosophila wing disc epithelia by regulating Rho1.
Present address: Centre de Regulació Genòmica, 08003 Barcelona, Spain. 
To whom correspondence should be addressed. E-mail: 
