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Regulation of Versus ß T Lymphocyte Differentiation by the Transcription Factor SOX13
Heather J. Melichar,1Kavitha Narayan,1Sandy D. Der,2Yoshiki Hiraoka,3Noemie Gardiol,4Gregoire Jeannet,4Werner Held,4Cynthia A. Chambers,1Joonsoo Kang1*
ß and T cells originate from a common, multipotentialprecursor population in the thymus, but the molecular mechanismsregulating this lineage-fate decision are unknown. We have identifiedSox13 as a -specific gene in the immune system. Using Sox13transgenic mice, we showed that this transcription factor promotes T cell development while opposing ß T cell differentiation.Conversely, mice deficient in Sox13 expression exhibited impaireddevelopment of T cells but not ß T cells. One mechanismof SOX13 function is the inhibition of signaling by the developmentallyimportant Wnt/T cell factor (TCF) pathway. Our data thus reveala dominant pathway regulating the developmental fate of thesetwo lineages of T lymphocytes.
1 Department of Pathology, Graduate Program in Immunology and Virology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA. 2 Department of Laboratory Medicine and Pathobiology, Program in Proteomics and Bioinformatics, University of Toronto, Toronto, Canada. 3 Department of Anatomy, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. 4 Ludwig Institute for Cancer Research, Lausanne Branch and University of Lausanne, Chemin Des Boveresses 155, 1066 Epalinges, Switzerland.
* To whom correspondence should be addressed. E-mail: Joonsoo.Kang{at}umassmed.edu
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Versus 
ß T Lymphocyte Differentiation by the Transcription Factor SOX13
ß and 
T cells originate from a common, multipotential precursor population in the thymus, but the molecular mechanisms regulating this lineage-fate decision are unknown. We have identified Sox13 as a 
