Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Comment on "A Common Genetic Variant Is Associated with Adult and Childhood Obesity"
Ruth J. F. Loos,1*Inês Barroso,2Stephen O'Rahilly,3Nicholas J. Wareham1
Herbert et al. (Reports, 14 April 2006, p. 279) found that thers7566605 genetic variant, located upstream of the INSIG2 gene,was consistently associated with increased body mass index.However, we found no evidence of association between rs7566605and body mass index in two large ethnically homogeneous population-basedcohorts. On the contrary, an opposite tendency was observed.
1 Medical Research Council Epidemiology Unit, Cambridge, UK. 2 Metabolic Disease Group, The Wellcome Trust Sanger Institute, Hinxton, UK. 3 University Department of Clinical Biochemistry, Cambridge Institute for Medical Research, Cambridge, UK.
* To whom correspondence should be addressed. E-mail: ruth.loos{at}mrc-epid.cam.ac.uk
The editors suggest the following Related Resources on Science sites:
In Science Magazine
TECHNICAL COMMENTS
Christian Dina, David Meyre, Chantal Samson, Jean Tichet, Michel Marre, Beatrice Jouret, Marie Aline Charles, Beverley Balkau, and Philippe Froguel (12 January 2007) Science315 (5809), 187b.
[DOI: 10.1126/science.1129402] |Abstract »|Full Text »|PDF »
TECHNICAL COMMENTS
Dieter Rosskopf, Alexa Bornhorst, Christian Rimmbach, Christian Schwahn, Alexander Kayser, Anne Krüger, Grietje Tessmann, Ingrid Geissler, Heyo K. Kroemer, and Henry Völzke (12 January 2007) Science315 (5809), 187d.
[DOI: 10.1126/science.1130571] |Abstract »|Full Text »|PDF »
TECHNICAL COMMENTS
Alan Herbert, Norman P. Gerry, Matthew B. McQueen, Iris M. Heid, Arne Pfeufer, Thomas Illig, H.-Erich Wichmann, Thomas Meitinger, David Hunter, Frank B. Hu, Graham Colditz, Anke Hinney, Johannes Hebebrand, Kerstin Koberwitz, Xiaofeng Zhu, Richard Cooper, Kristin Ardlie, Helen Lyon, Joel N. Hirschhorn, Nan M. Laird, Marc E. Lenburg, Christoph Lange, and Michael F. Christman (12 January 2007) Science315 (5809), 187e.
[DOI: 10.1126/science.1129763] |Abstract »|Full Text »|PDF »
REPORTS
Alan Herbert, Norman P. Gerry, Matthew B. McQueen, Iris M. Heid, Arne Pfeufer, Thomas Illig, H.-Erich Wichmann, Thomas Meitinger, David Hunter, Frank B. Hu, Graham Colditz, Anke Hinney, Johannes Hebebrand, Kerstin Koberwitz, Xiaofeng Zhu, Richard Cooper, Kristin Ardlie, Helen Lyon, Joel N. Hirschhorn, Nan M. Laird, Marc E. Lenburg, Christoph Lange, and Michael F. Christman (14 April 2006) Science312 (5771), 279.
[DOI: 10.1126/science.1124779] |Abstract »|Full Text »|PDF »|Supporting Online Material »
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A common VLDLR polymorphism interacts with APOE genotype in the prediction of carotid artery disease risk.
D. C. Crawford, A. S. Nord, M. D. Badzioch, J. Ranchalis, L. A. McKinstry, M. Ahearn, C. Bertucci, C. Shephard, M. Wong, M. J. Rieder, et al. (2008)
J. Lipid Res.
49, 588-596
|Abstract »|Full Text »|PDF »
Evidence of an Influence of a Polymorphism Near the INSIG2 on Weight Loss During a Lifestyle Intervention in Obese Children and Adolescents.
T. Reinehr, A. Hinney, T. T. Nguyen, and J. Hebebrand (2008)
Diabetes
57, 623-626
|Abstract »|Full Text »|PDF »
