Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Herbert et al. (Reports, 14 April 2006, p. 279) reported anassociation between the INSIG2 gene variant rs7566605 and obesityin four sample populations, under a recessive model. We attemptedto replicate this result in 10,265 Caucasian individuals, combiningfamily-based, case-control, and general population studies,but found no support for a major role of this variant in obesity.
1 CNRS 8090-Institute of Biology, Pasteur Institute, Lille, France. 2 Institut Inter-Régional pour la Santé, Tours, France. 3 Department of Diabetology, Bichat Claude Bernard Hospital, Assistance Publique-Hôpitaux de Paris, France. 4 Institut National de la Santé et de la Recherche Médicale (INSERM) U563, Children's Hospital, Toulouse, France. 5 INSERM U780-IFR69, Villejuif, France. 6 Université Paris-Sud, Villejuif, France. 7 Department of Genomic Medicine, Imperial College London, UK.
* To whom correspondence should be addressed. E-mail: dina{at}good.ibl.fr
The editors suggest the following Related Resources on Science sites:
In Science Magazine
TECHNICAL COMMENTS
Ruth J. F. Loos, Inês Barroso, Stephen O'Rahilly, and Nicholas J. Wareham (12 January 2007) Science315 (5809), 187c.
[DOI: 10.1126/science.1130012] |Abstract »|Full Text »|PDF »
TECHNICAL COMMENTS
Dieter Rosskopf, Alexa Bornhorst, Christian Rimmbach, Christian Schwahn, Alexander Kayser, Anne Krüger, Grietje Tessmann, Ingrid Geissler, Heyo K. Kroemer, and Henry Völzke (12 January 2007) Science315 (5809), 187d.
[DOI: 10.1126/science.1130571] |Abstract »|Full Text »|PDF »
TECHNICAL COMMENTS
Alan Herbert, Norman P. Gerry, Matthew B. McQueen, Iris M. Heid, Arne Pfeufer, Thomas Illig, H.-Erich Wichmann, Thomas Meitinger, David Hunter, Frank B. Hu, Graham Colditz, Anke Hinney, Johannes Hebebrand, Kerstin Koberwitz, Xiaofeng Zhu, Richard Cooper, Kristin Ardlie, Helen Lyon, Joel N. Hirschhorn, Nan M. Laird, Marc E. Lenburg, Christoph Lange, and Michael F. Christman (12 January 2007) Science315 (5809), 187e.
[DOI: 10.1126/science.1129763] |Abstract »|Full Text »|PDF »
REPORTS
Alan Herbert, Norman P. Gerry, Matthew B. McQueen, Iris M. Heid, Arne Pfeufer, Thomas Illig, H.-Erich Wichmann, Thomas Meitinger, David Hunter, Frank B. Hu, Graham Colditz, Anke Hinney, Johannes Hebebrand, Kerstin Koberwitz, Xiaofeng Zhu, Richard Cooper, Kristin Ardlie, Helen Lyon, Joel N. Hirschhorn, Nan M. Laird, Marc E. Lenburg, Christoph Lange, and Michael F. Christman (14 April 2006) Science312 (5771), 279.
[DOI: 10.1126/science.1124779] |Abstract »|Full Text »|PDF »|Supporting Online Material »
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A common VLDLR polymorphism interacts with APOE genotype in the prediction of carotid artery disease risk.
D. C. Crawford, A. S. Nord, M. D. Badzioch, J. Ranchalis, L. A. McKinstry, M. Ahearn, C. Bertucci, C. Shephard, M. Wong, M. J. Rieder, et al. (2008)
J. Lipid Res.
49, 588-596
|Abstract »|Full Text »|PDF »
Evidence of an Influence of a Polymorphism Near the INSIG2 on Weight Loss During a Lifestyle Intervention in Obese Children and Adolescents.
T. Reinehr, A. Hinney, T. T. Nguyen, and J. Hebebrand (2008)
Diabetes
57, 623-626
|Abstract »|Full Text »|PDF »
