Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 12 January 2007:
Vol. 315. no. 5809, p. 187
DOI: 10.1126/science.1129402
Prev | Table of Contents | Next

Technical Comments

Comment on "A Common Genetic Variant Is Associated with Adult and Childhood Obesity"

Christian Dina,1* David Meyre,1 Chantal Samson,1 Jean Tichet,2 Michel Marre,3 Beatrice Jouret,4 Marie Aline Charles,5,6 Beverley Balkau,5,6 Philippe Froguel1,7

Herbert et al. (Reports, 14 April 2006, p. 279) reported an association between the INSIG2 gene variant rs7566605 and obesity in four sample populations, under a recessive model. We attempted to replicate this result in 10,265 Caucasian individuals, combining family-based, case-control, and general population studies, but found no support for a major role of this variant in obesity.

1 CNRS 8090-Institute of Biology, Pasteur Institute, Lille, France.
2 Institut Inter-Régional pour la Santé, Tours, France.
3 Department of Diabetology, Bichat Claude Bernard Hospital, Assistance Publique-Hôpitaux de Paris, France.
4 Institut National de la Santé et de la Recherche Médicale (INSERM) U563, Children's Hospital, Toulouse, France.
5 INSERM U780-IFR69, Villejuif, France.
6 Université Paris-Sud, Villejuif, France.
7 Department of Genomic Medicine, Imperial College London, UK.

* To whom correspondence should be addressed. E-mail: dina{at}good.ibl.fr

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A common VLDLR polymorphism interacts with APOE genotype in the prediction of carotid artery disease risk.
D. C. Crawford, A. S. Nord, M. D. Badzioch, J. Ranchalis, L. A. McKinstry, M. Ahearn, C. Bertucci, C. Shephard, M. Wong, M. J. Rieder, et al. (2008)
J. Lipid Res. 49, 588-596
   Abstract »    Full Text »    PDF »
Evidence of an Influence of a Polymorphism Near the INSIG2 on Weight Loss During a Lifestyle Intervention in Obese Children and Adolescents.
T. Reinehr, A. Hinney, T. T. Nguyen, and J. Hebebrand (2008)
Diabetes 57, 623-626
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)