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Members of the Notch family of receptors act as membrane-tetheredtranscription factors that are tightly associated with binarycell fate decisions. Notch signaling acts as a molecular gatethat allows cells to adopt or forfeit a particular fate. Interactionof Notch with ligands triggers a sequence of proteolytic cleavagesthat release the intracellular domain to the nucleus; this mechanismis a target of therapies for leukemias associated with Notchactivation. Although the molecular mechanism of Notch activationis well characterized, further analysis in an appropriate cellularcontext will provide new insight into Notch signaling.
1 Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK. 2 Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK.
* To whom correspondence should be addressed. E-mail: ama11{at}hermes.cam.ac.uk
