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Two Dobzhansky-Muller Genes Interact to Cause Hybrid Lethality in Drosophila
Nicholas J. Brideau,*Heather A. Flores,*Jun Wang,*Shamoni Maheshwari,Xu Wang,Daniel A. Barbash
The Dobzhansky-Muller model proposes that hybrid incompatibilitiesare caused by the interaction between genes that have functionallydiverged in the respective hybridizing species. Here, we showthat Lethal hybrid rescue (Lhr) has functionally diverged inDrosophila simulans and interacts with Hybrid male rescue (Hmr),which has functionally diverged in D. melanogaster, to causelethality in F1 hybrid males. LHR localizes to heterochromaticregions of the genome and has diverged extensively in sequencebetween these species in a manner consistent with positive selection.Rapidly evolving heterochromatic DNA sequences may be drivingthe evolution of this incompatibility gene.
Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.
* These authors contributed equally to this work.
To whom correspondence should be addressed. E-mail: dab87{at}cornell.edu
To whom correspondence should be addressed. E-mail: 
