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Science 24 November 2006:
Vol. 314. no. 5803, p. 1243
DOI: 10.1126/science.1129917
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Technical Comments

Response to Comment on Suri et al. on Diabetes Reversal in NOD Mice

Anish Suri and Emil R Unanue*

Faustman et al. present no new information to explain why three independent laboratories failed to reproduce their previous results implicating spleen cell transdifferentiation in the reversal of murine type 1 diabetes. Modulation of the immunological process in nonobese diabetic (NOD) mice has been accomplished by many laboratories using different protocols and does not represent a novel finding in their work.

Department of Pathology and Immunology, Washington University School of Medicine St. Louis, MO, 63110, USA.

* To whom correspondence should be addressed. E-mail: unanue{at}pathbox.wustl.edu

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Science. ISSN 0036-8075 (print), 1095-9203 (online)