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Science 24 November 2006:
Vol. 314. no. 5803, p. 1243
DOI: 10.1126/science.1129918

Technical Comments

Response to Comment on Chong et al. on Diabetes Reversal in NOD Mice

Anita S. Chong,1* Jikun Shen,1 Jing Tao,1 Dengping Yin,1,3 Andrey Kuznetsov,2 Manami Hara,2 Louis H. Philipson2

We failed to detect transdifferentiation of spleen cells into ß cells following diabetes reversal in nonobese diabetic (NOD) mice, thus contradicting a key finding of a 2003 report. We respond to Faustman et al. by justifying the use of mouse insulin promoter–green fluorescent protein transgenic mice as an appropriate system for detecting spleen-derived ß cells in the islets of cured NOD mice.

1 Section of Transplantation, Department of Surgery, University of Chicago, Chicago, IL 60637, USA.
2 Section of Endocrinology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA.
3 Department of Surgery, University of Illinois at Chicago, Chicago, IL 60612, USA.

* To whom correspondence should be addressed. E-mail: achong{at}uchicago.edu

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Science. ISSN 0036-8075 (print), 1095-9203 (online)