Response to Comment on Chong et al. on Diabetes Reversal in NOD Mice
Anita S. Chong,1*
Jikun Shen,1
Jing Tao,1
Dengping Yin,1,3
Andrey Kuznetsov,2
Manami Hara,2
Louis H. Philipson2
We failed to detect transdifferentiation of spleen cells into
ß cells following diabetes reversal in nonobese diabetic
(NOD) mice, thus contradicting a key finding of a 2003 report.
We respond to Faustman
et al. by justifying the use of mouse
insulin promoter–green fluorescent protein transgenic
mice as an appropriate system for detecting spleen-derived ß
cells in the islets of cured NOD mice.
2 Section of Endocrinology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA.
3 Department of Surgery, University of Illinois at Chicago, Chicago, IL 60612, USA.
* To whom correspondence should be addressed. E-mail: achong{at}uchicago.edu
