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Response to Comment on Chong et al. on Diabetes Reversal in NOD Mice
Anita S. Chong,1*Jikun Shen,1Jing Tao,1Dengping Yin,1,3Andrey Kuznetsov,2Manami Hara,2Louis H. Philipson2
We failed to detect transdifferentiation of spleen cells intoß cells following diabetes reversal in nonobese diabetic(NOD) mice, thus contradicting a key finding of a 2003 report.We respond to Faustman et al. by justifying the use of mouseinsulin promoter–green fluorescent protein transgenicmice as an appropriate system for detecting spleen-derived ßcells in the islets of cured NOD mice.
1 Section of Transplantation, Department of Surgery, University of Chicago, Chicago, IL 60637, USA. 2 Section of Endocrinology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA. 3 Department of Surgery, University of Illinois at Chicago, Chicago, IL 60612, USA.
* To whom correspondence should be addressed. E-mail: achong{at}uchicago.edu
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