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ReportsSara Endosomes and the Maintenance of Dpp Signaling Levels Across Mitosis 
During development, cells acquire positional information by reading the concentration of morphogens. In the developing fly wing, a gradient of the transforming growth factor–ß (TGF-ß)–type morphogen decapentaplegic (Dpp) is transduced into a gradient of concentration of the phosphorylated form of the R-Smad transcription factor Mad. The endosomal protein Sara (Smad anchor for receptor activation) recruits R-Smads for phosphorylation by the type I TGF-ß receptor. We found that Sara, Dpp, and its type I receptor Thickveins were targeted to a subpopulation of apical endosomes in the developing wing epithelial cells. During mitosis, the Sara endosomes and the receptors therein associated with the spindle machinery to segregate into the two daughter cells. Daughter cells thereby inherited equal amounts of signaling molecules and thus retained the Dpp signaling levels of the mother cell.
1 Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany. * *Present address: Biotechnological Center, Dresden University of Technology, Tatzberg 47, 01307 Dresden, Germany.
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Present address: Automation Project, Plateforme d'Imagerie Dynamique, Institut Pasteur, 25–28, rue du Docteur Roux, 75015 Paris, France. 
To whom correspondence should be addressed. E-mail: 
Science. ISSN 0036-8075 (print), 1095-9203 (online)
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