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Science 15 September 2006: Vol. 313. no. 5793, pp. 1628 - 1632 DOI: 10.1126/science.1130773
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Reports
Caveolin-1 Is Essential for Liver Regeneration
Manuel A. Fernández,1,2*
Cecilia Albor,1*
Mercedes Ingelmo-Torres,1
Susan J. Nixon,2
Charles Ferguson,2
Teymuras Kurzchalia,3
Francesc Tebar,1
Carlos Enrich,1
Robert G. Parton,2
Albert Pol1
Liver regeneration is an orchestrated cellular response that coordinates cell activation, lipid metabolism, and cell division. We found that caveolin-1 genedisrupted mice ( cav1/ mice) exhibited impaired liver regeneration and low survival after a partial hepatectomy. Hepatocytes showed dramatically reduced lipid droplet accumulation and did not advance through the cell division cycle. Treatment of cav1/ mice with glucose (which is a predominant energy substrate when compared to lipids) drastically increased survival and reestablished progression of the cell cycle. Thus, caveolin-1 plays a crucial role in the mechanisms that coordinate lipid metabolism with the proliferative response occurring in the liver after cellular injury.
1 Departament de Biologia Cellular, Facultat de Medicina, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona, Casanova 143, 08036 Barcelona, Spain.
2 Institute for Molecular Bioscience, Centre for Microscopy and Microanalysis and School of Biomedical Sciences, University of Queensland, Brisbane, Queensland 4072, Australia.
3 Max-Plank-Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany.
* These authors contributed equally to this work.
To whom correspondence should be addressed. E-mail: R.Parton{at}imb.uq.edu.au (R.G.P.); apols{at}ub.edu (A.P.).
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