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Manuel A. Fernández,1,2*Cecilia Albor,1*Mercedes Ingelmo-Torres,1Susan J. Nixon,2Charles Ferguson,2Teymuras Kurzchalia,3Francesc Tebar,1Carlos Enrich,1Robert G. Parton,2Albert Pol1
Liver regeneration is an orchestrated cellular response thatcoordinates cell activation, lipid metabolism, and cell division.We found that caveolin-1 gene–disrupted mice (cav1–/–mice) exhibited impaired liver regeneration and low survivalafter a partial hepatectomy. Hepatocytes showed dramaticallyreduced lipid droplet accumulation and did not advance throughthe cell division cycle. Treatment of cav1–/– micewith glucose (which is a predominant energy substrate when comparedto lipids) drastically increased survival and reestablishedprogression of the cell cycle. Thus, caveolin-1 plays a crucialrole in the mechanisms that coordinate lipid metabolism withthe proliferative response occurring in the liver after cellularinjury.
1 Departament de Biologia Cellular, Facultat de Medicina, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona, Casanova 143, 08036 Barcelona, Spain. 2 Institute for Molecular Bioscience, Centre for Microscopy and Microanalysis and School of Biomedical Sciences, University of Queensland, Brisbane, Queensland 4072, Australia. 3 Max-Plank-Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany.
* These authors contributed equally to this work.
To whom correspondence should be addressed. E-mail: R.Parton{at}imb.uq.edu.au (R.G.P.); apols{at}ub.edu (A.P.).
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