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Science 15 September 2006:
Vol. 313. no. 5793, p. 1573
DOI: 10.1126/science.1131840
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Technical Comments

Response to Comment on "Large-Scale Sequence Analysis of Avian Influenza Isolates"

John C. Obenauer,1 Yiping Fan,1 Clayton W. Naeve1,2*

We repeated the dN/dS analysis as described by Holmes et al. using the methods and data as described in our original report. We obtained essentially the same results and agree that it cannot be concluded from dN/dS calculations whether PB1-F2 is under positive, negative, or neutral selection.

1 Hartwell Center for Bioinformatics and Biotechnology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
2 Department of Pathology, University of Tennessee Health Science Center, Memphis, TN 38163, USA.

* To whom correspondence should be addressed. E-mail: clayton.naeve{at}stjude.org

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Science. ISSN 0036-8075 (print), 1095-9203 (online)