Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 1 September 2006:
Vol. 313. no. 5791, pp. 1310 - 1312
DOI: 10.1126/science.1128197
Prev | Table of Contents | Next

Reports

A Role for the Macaque Anterior Cingulate Gyrus in Social Valuation

P. H. Rudebeck,* M. J. Buckley, M. E. Walton, M. F. S. Rushworth

Complex human social interaction is disrupted when the frontal lobe is damaged in disease, and in extreme cases patients are described as having acquired sociopathy. We compared, in macaques, the effects of lesions in subdivisions of the anterior cingulate and the orbitofrontal cortices believed to be anatomically homologous to those damaged in such patients. We show that the anterior cingulate gyrus in male macaques is critical for normal patterns of social interest in other individual male or female macaques. Conversely, the orbitofrontal cortex lesion had a marked effect only on responses to mildly fear-inducing stimuli. These results suggest that damage to the anterior cingulate gyrus may be the cause of changes in social interaction seen after frontal lobe damage.

Department of Experimental Psychology, University of Oxford, Oxford, OX1 3UD, UK.

* To whom correspondence should be addressed. E-mail: peter.rudebeck{at}psy.ox.ac.uk

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Dissociable Components of Rule-Guided Behavior Depend on Distinct Medial and Prefrontal Regions.
M. J. Buckley, F. A. Mansouri, H. Hoda, M. Mahboubi, P. G. F. Browning, S. C. Kwok, A. Phillips, and K. Tanaka (2009)
Science 325, 52-58
   Abstract »    Full Text »    PDF »
The Computation of Social Behavior.
T. E. J. Behrens, L. T. Hunt, and M. F. S. Rushworth (2009)
Science 324, 1160-1164
   Abstract »    Full Text »    PDF »
Fictive Reward Signals in the Anterior Cingulate Cortex.
B. Y. Hayden, J. M. Pearson, and M. L. Platt (2009)
Science 324, 948-950
   Abstract »    Full Text »    PDF »
Connectivity-Based Parcellation of Human Cingulate Cortex and Its Relation to Functional Specialization.
M. Beckmann, H. Johansen-Berg, and M. F. S. Rushworth (2009)
J. Neurosci. 29, 1175-1190
   Abstract »    Full Text »    PDF »
Distinct Effects of {Delta}9-Tetrahydrocannabinol and Cannabidiol on Neural Activation During Emotional Processing.
P. Fusar-Poli, J. A. Crippa, S. Bhattacharyya, S. J. Borgwardt, P. Allen, R. Martin-Santos, M. Seal, S. A. Surguladze, C. O'Carrol, Z. Atakan, et al. (2009)
Arch Gen Psychiatry 66, 95-105
   Abstract »    Full Text »    PDF »
Frontal Cortex Subregions Play Distinct Roles in Choices between Actions and Stimuli.
P. H. Rudebeck, T. E. Behrens, S. W. Kennerley, M. G. Baxter, M. J. Buckley, M. E. Walton, and M. F. S. Rushworth (2008)
J. Neurosci. 28, 13775-13785
   Abstract »    Full Text »    PDF »
Neuroethology of reward and decision making.
K. K Watson and M. L Platt (2008)
Phil Trans R Soc B 363, 3825-3835
   Abstract »    Full Text »    PDF »
The contribution of distinct subregions of the ventromedial frontal cortex to emotion, social behavior, and decision making.
P. H. Rudebeck, D. M. Bannerman, and M. F. S. Rushworth (2008)
Cogn Affect Behav Neurosci 8, 485-497
   Abstract »    PDF »
Cells, circuits, and choices: Social influences on perceptual decision making.
A. Mojzisch and K. Krug (2008)
Cogn Affect Behav Neurosci 8, 498-508
   Abstract »    PDF »
Women with autistic-spectrum disorder: magnetic resonance imaging study of brain anatomy.
M. C. Craig, S. H. Zaman, E. M. Daly, W. J. Cutter, D. M. W. Robertson, B. Hallahan, F. Toal, S. Reed, A. Ambikapathy, M. Brammer, et al. (2007)
The British Journal of Psychiatry 191, 224-228
   Abstract »    Full Text »    PDF »
When Fear Is Near: Threat Imminence Elicits Prefrontal-Periaqueductal Gray Shifts in Humans.
D. Mobbs, P. Petrovic, J. L. Marchant, D. Hassabis, N. Weiskopf, B. Seymour, R. J. Dolan, and C. D. Frith (2007)
Science 317, 1079-1083
   Abstract »    Full Text »    PDF »
Functional Specialization of the Primate Frontal Cortex during Decision Making.
D. Lee, M. F. S. Rushworth, M. E. Walton, M. Watanabe, and M. Sakagami (2007)
J. Neurosci. 27, 8170-8173
   Abstract »    Full Text »    PDF »
Patterning of frontal cortex subdivisions by Fgf17.
J. A. Cholfin and J. L. R. Rubenstein (2007)
PNAS 104, 7652-7657
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)