Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
AAAS Store

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 25 August 2006:
Vol. 313. no. 5790, pp. 1100 - 1104
DOI: 10.1126/science.1128640
Prev | Table of Contents | Next

Reports

Detection, Stimulation, and Inhibition of Neuronal Signals with High-Density Nanowire Transistor Arrays

Fernando Patolsky,1* Brian P. Timko,1* Guihua Yu,1 Ying Fang,1 Andrew B. Greytak,1 Gengfeng Zheng,1 Charles M. Lieber1,2{dagger}

We report electrical properties of hybrid structures consisting of arrays of nanowire field-effect transistors integrated with the individual axons and dendrites of live mammalian neurons, where each nanoscale junction can be used for spatially resolved, highly sensitive detection, stimulation, and/or inhibition of neuronal signal propagation. Arrays of nanowire-neuron junctions enable simultaneous measurement of the rate, amplitude, and shape of signals propagating along individual axons and dendrites. The configuration of nanowire-axon junctions in arrays, as both inputs and outputs, makes possible controlled studies of partial to complete inhibition of signal propagation by both local electrical and chemical stimuli. In addition, nanowire-axon junction arrays were integrated and tested at a level of at least 50 "artificial synapses" per neuron.

1 Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
2 Division of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.

* These authors contributed equally to this work.

{dagger} To whom correspondence should be addressed. E-mail: cml{at}cmliris.harvard.edu

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Two-Photon Excitation of Potentiometric Probes Enables Optical Recording of Action Potentials From Mammalian Nerve Terminals In Situ.
J. A. N. Fisher, J. R. Barchi, C. G. Welle, G.-H. Kim, P. Kosterin, A. L. Obaid, A. G. Yodh, D. Contreras, and B. M. Salzberg (2008)
J Neurophysiol 99, 1545-1553
   Abstract »    Full Text »    PDF »
Interfacing Neurons with Carbon Nanotubes: Electrical Signal Transfer and Synaptic Stimulation in Cultured Brain Circuits.
A. Mazzatenta, M. Giugliano, S. Campidelli, L. Gambazzi, L. Businaro, H. Markram, M. Prato, and L. Ballerini (2007)
J. Neurosci. 27, 6931-6936
   Abstract »    Full Text »    PDF »
Direct-Current Nanogenerator Driven by Ultrasonic Waves.
X. Wang, J. Song, J. Liu, and Z. L. Wang (2007)
Science 316, 102-105
   Abstract »    Full Text »    PDF »


ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products