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Science 25 August 2006:
Vol. 313. no. 5790, pp. 1100 - 1104
DOI: 10.1126/science.1128640
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Reports

Detection, Stimulation, and Inhibition of Neuronal Signals with High-Density Nanowire Transistor Arrays

Fernando Patolsky,1* Brian P. Timko,1* Guihua Yu,1 Ying Fang,1 Andrew B. Greytak,1 Gengfeng Zheng,1 Charles M. Lieber1,2{dagger}

We report electrical properties of hybrid structures consisting of arrays of nanowire field-effect transistors integrated with the individual axons and dendrites of live mammalian neurons, where each nanoscale junction can be used for spatially resolved, highly sensitive detection, stimulation, and/or inhibition of neuronal signal propagation. Arrays of nanowire-neuron junctions enable simultaneous measurement of the rate, amplitude, and shape of signals propagating along individual axons and dendrites. The configuration of nanowire-axon junctions in arrays, as both inputs and outputs, makes possible controlled studies of partial to complete inhibition of signal propagation by both local electrical and chemical stimuli. In addition, nanowire-axon junction arrays were integrated and tested at a level of at least 50 "artificial synapses" per neuron.

1 Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
2 Division of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.

* These authors contributed equally to this work.

{dagger} To whom correspondence should be addressed. E-mail: cml{at}cmliris.harvard.edu

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Science. ISSN 0036-8075 (print), 1095-9203 (online)