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Science 25 August 2006:
Vol. 313. no. 5790, p. 1045
DOI: 10.1126/science.1128552
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Technical Comments

Response to Comment on "Cell Type Regulates Selective Segregation of Mouse Chromosome 7 DNA Strands in Mitosis"

Amar J. S. Klar1* and Athanasios Armakolas2

To explain how all chromosome recombinants can become homozygous for a marker located distal to the crossover point, we proposed that mitotic recombination must be restricted to two specific chromatids and that the selective chromatid segregation process follows recombination. We refute Haber's contention that our results can be explained by the conventional X-segregation process if recombination of all possible combinations of chromatids is considered.

1 Laboratory of Gene Expression and Chromosome Biology, National Cancer Institute at Frederick, P.O. Box B, Frederick, MD 21702–1201, USA.
2 Hippokrateion Hospital of Athens, Laboratory of Surgical Research, Vassilisis Sofias 114, Athens 11527, Greece.

* To whom correspondence should be addressed. E-mail: klar{at}ncifcrf.gov

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Left-Right Dynein Motor Implicated in Selective Chromatid Segregation in Mouse Cells.
A. Armakolas and A. J. S. Klar (2007)
Science 315, 100-101
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