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Requirement for Coronin 1 in T Lymphocyte Trafficking and Cellular Homeostasis
Niko Föger,1Linda Rangell,2Dimitry M. Danilenko,2Andrew C. Chan1*
The evolutionarily conserved actin-related protein (Arp2/3)complex is a key component of actin filament networks that isdynamically regulated by nucleation-promoting and inhibitoryfactors. Although much is known about actin assembly, the physiologicfunctions of inhibitory proteins are unclear. We generated coronin1–/– mice and found that coronin 1 exerted an inhibitoryeffect on cellular steady-state F-actin formation via an Arp2/3-dependentmechanism. Whereas coronin 1 was required for chemokine-mediatedmigration, it was dispensable for T cell antigen receptor functionsin T cells. Moreover, actin dynamics, through a mitochondrialpathway, was linked to lymphocyte homeostasis.
1 Department of Immunology, Genentech, Incorporated, 1 DNA Way, South San Francisco, CA 94080, USA. 2 Department of Pathology, Genentech, Incorporated, 1 DNA Way, South San Francisco, CA 94080, USA.
* To whom correspondence should be addressed. E-mail: acc{at}gene.com
IFN-{gamma} and STAT1 Arrest Monocyte Migration and Modulate RAC/CDC42 Pathways.
Y. Hu, X. Hu, L. Boumsell, and L. B. Ivashkiv (2008)
J. Immunol.
180, 8057-8065
|Abstract »|Full Text »|PDF »
RNA Interference in J774 Macrophages Reveals a Role for Coronin 1 in Mycobacterial Trafficking but Not in Actin-dependent Processes.
R. Jayachandran, J. Gatfield, J. Massner, I. Albrecht, B. Zanolari, and J. Pieters (2008)
Mol. Biol. Cell
19, 1241-1251
|Abstract »|Full Text »|PDF »
T Cell Responses in Mammalian Diaphanous-related Formin mDia1 Knock-out Mice.
K. M. Eisenmann, R. A. West, D. Hildebrand, S. M. Kitchen, J. Peng, R. Sigler, J. Zhang, K. A. Siminovitch, and A. S. Alberts (2007)
J. Biol. Chem.
282, 25152-25158
|Abstract »|Full Text »|PDF »
Lipoamide dehydrogenase mediates retention of coronin-1 on BCG vacuoles, leading to arrest in phagosome maturation.
A.-E. Deghmane, H. Soualhine, H. Bach, K. Sendide, S. Itoh, A. Tam, S. Noubir, A. Talal, R. Lo, S. Toyoshima, et al. (2007)
J. Cell Sci.
120, 2796-2806
|Abstract »|Full Text »|PDF »
Actin-binding Proteins Coronin-1a and IBA-1 Are Effective Microglial Markers for Immunohistochemistry.
Z. Ahmed, G. Shaw, V. P. Sharma, C. Yang, E. McGowan, and D. W. Dickson (2007)
J. Histochem. Cytochem.
55, 687-700
|Abstract »|Full Text »|PDF »
F-actin binding is essential for coronin 1B function in vivo.
