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A Bacterial Virulence Protein Suppresses Host Innate Immunity to Cause Plant Disease
Kinya Nomura,1Sruti DebRoy,1Yong Hoon Lee,1Nathan Pumplin,1Jonathan Jones,2Sheng Yang He1*
Plants have evolved a powerful immune system to defend againstinfection by most microbial organisms. However, successful pathogens,such as Pseudomonas syringae, have developed countermeasuresand inject virulence proteins into the host plant cell to suppressimmunity and cause devastating diseases. Despite intensive researchefforts, the molecular targets of bacterial virulence proteinsthat are important for plant disease development have remainedobscure. Here, we show that a conserved P. syringae virulenceprotein, HopM1, targets an immunity-associated protein, AtMIN7,in Arabidopsis thaliana. HopM1 mediates the destruction of AtMIN7via the host proteasome. Our results illustrate a strategy bywhich a bacterial pathogen exploits the host proteasome to subverthost immunity and causes infection in plants.
1 Department of Energy Plant Research Laboratory, Department of Plant Biology, Michigan State University, East Lansing, MI 48824, USA. 2 Sainsbury Laboratory, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK.
* To whom correspondence should be addressed. E-mail: hes{at}msu.edu
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F. A. R. Kaffarnik, A. M. E. Jones, J. P. Rathjen, and S. C. Peck (2009)
Mol. Cell. Proteomics
8, 145-156
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Secretory Pathways in Plant Immune Responses.
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D. Dou, S. D. Kale, X. Wang, Y. Chen, Q. Wang, X. Wang, R. H.Y. Jiang, F. D. Arredondo, R. G. Anderson, P. B. Thakur, et al. (2008)
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H. Chen, Y. Zou, Y. Shang, H. Lin, Y. Wang, R. Cai, X. Tang, and J.-M. Zhou (2008)
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146, 368-376
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B. H. Kvitko, A. R. Ramos, J. E. Morello, H.-S. Oh, and A. Collmer (2007)
J. Bacteriol.
189, 8059-8072
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Large-Scale, Lineage-Specific Expansion of a Bric-a-Brac/Tramtrack/Broad Complex Ubiquitin-Ligase Gene Family in Rice.
D. J. Gingerich, K. Hanada, S.-H. Shiu, and R. D. Vierstra (2007)
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The syntaxin SYP132 contributes to plant resistance against bacteria and secretion of pathogenesis-related protein 1.
M. Kalde, T. S. Nuhse, K. Findlay, and S. C. Peck (2007)
PNAS
104, 11850-11855
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