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Science 30 June 2006:
Vol. 312. no. 5782, pp. 1946 - 1949
DOI: 10.1126/science.1128004
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Reports

Lhx2 Maintains Stem Cell Character in Hair Follicles

Horace Rhee, Lisa Polak, Elaine Fuchs*

During embryogenesis, stem cells are set aside to fuel the postnatal hair cycle and repair the epidermis after injury. To define how hair follicle stem cells are specified and maintained in an undifferentiated state, we developed a strategy to isolate and transcriptionally profile embryonic hair progenitors in mice. We identified Lhx2 as a transcription factor positioned downstream of signals necessary to specify hair follicle stem cells, but upstream from signals required to drive activated stem cells to terminally differentiate. Using gain- and loss-of-function studies, we uncovered a role for Lhx2 in maintaining the growth and undifferentiated properties of hair follicle progenitors.

Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY 10021.

* To whom correspondence should be addressed. E-mail: fuchslb{at}rockefeller.edu

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The lamin B receptor under transcriptional control of C/EBP{varepsilon} is required for morphological but not functional maturation of neutrophils.
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