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Science 2 June 2006:
Vol. 312. no. 5778, p. 1312
DOI: 10.1126/science.1124767
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Technical Comments

Response to Comment on "HST2 Mediates SIR2-Independent Life-Span Extension by Calorie Restriction"

Dudley W. Lamming,1 Magda Latorre-Esteves,1 Oliver Medvedik,1 Stacy N. Wong,2 Felicia A. Tsang,2 Chen Wang,2 Su-Ju Lin,2* David A. Sinclair1*

Our two labs and others have shown that SIR2 controls the life span of diverse species, including Saccharomyces cerevisiae and Drosophila melanogaster, and that deleting SIR2 blocks life-span extension by calorie restriction. The methods of Kaeberlein et al. allow yeast to bypass the requirement for SIR2 and its homologs, which brings into question their suitability for modeling the physiology of more complex organisms.

1 Paul F. Glenn Laboratories, Department of Pathology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
2 Center for Genetics and Development and Section of Microbiology, University of California, Davis, 351 Briggs Hall, Davis, CA 95616, USA.

* To whom correspondence should be addressed. E-mail: slin{at}ucdavis.edu (S.-J.L.); david_sinclair{at}hms.harvard.edu (D.A.S.)

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Science. ISSN 0036-8075 (print), 1095-9203 (online)