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For many years, discoveries about the genetic determinants ofcancer appeared to be having only minor effects on efforts tocontrol the disease in the clinic. Following advances made overthe past decade, however, a description of cancer in molecularterms seems increasingly likely to improve the ways in whichhuman cancers are detected, classified, monitored, and (especially)treated. Achieving the medical promise of this new era in cancerresearch will require a deeper understanding of the biologyof cancer and imaginative application of new knowledge in theclinic, as well as political, social, and cultural changes.
Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
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