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Wnt Gradient Formation Requires Retromer Function in Wnt-Producing Cells
Damien Y. M. Coudreuse,Giulietta Roël,*Marco C. Betist,*Olivier Destrée,Hendrik C. Korswagen
Wnt proteins function as morphogens that can form long-rangeconcentration gradients to pattern developing tissues. Here,we show that the retromer, a multiprotein complex involved inintracellular protein trafficking, is required for long-rangesignaling of the Caenorhabditis elegans Wnt ortholog EGL-20.The retromer functions in EGL-20–producing cells to allowthe formation of an EGL-20 gradient along the anteroposterioraxis. This function is evolutionarily conserved, because Wnttarget gene expression is also impaired in the absence of theretromer complex in vertebrates. These results demonstrate thatthe ability of Wnt to regulate long-range patterning eventsis dependent on a critical and conserved function of the retromercomplex within Wnt-producing cells.
Hubrecht Laboratory and Center for Biomedical Genetics, Uppsalalaan 8, 3584 CT, Utrecht, Netherlands.
* These authors contributed equally to this work.
To whom correspondence should be addressed. E-mail: rkors{at}niob.knaw.nl
Complex Network of Wnt Signaling Regulates Neuronal Migrations During Caenorhabditis elegans Development.
A. Y. Zinovyeva, Y. Yamamoto, H. Sawa, and W. C. Forrester (2008)
Genetics
179, 1357-1371
|Abstract »|Full Text »|PDF »
An in Vivo Map of the Yeast Protein Interactome.
K. Tarassov, V. Messier, C. R. Landry, S. Radinovic, M. M. S. Molina, I. Shames, Y. Malitskaya, J. Vogel, H. Bussey, and S. W. Michnick (2008)
Science
320, 1465-1470
|Abstract »|Full Text »|PDF »
Retromer Sorting: A Pathogenic Pathway in Late-Onset Alzheimer Disease.
Arabidopsis VPS35, a Retromer Component, is Required for Vacuolar Protein Sorting and Involved in Plant Growth and Leaf Senescence.
M. Yamazaki, T. Shimada, H. Takahashi, K. Tamura, M. Kondo, M. Nishimura, and I. Hara-Nishimura (2008)
Plant Cell Physiol.
49, 142-156
|Abstract »|Full Text »|PDF »
Drosophila Vps35 function is necessary for normal endocytic trafficking and actin cytoskeleton organisation.
V. I. Korolchuk, M. M. Schutz, C. Gomez-Llorente, J. Rocha, N. R. Lansu, S. M. Collins, Y. P. Wairkar, I. M. Robinson, and C. J. O'Kane (2007)
J. Cell Sci.
120, 4367-4376
|Abstract »|Full Text »|PDF »
The C. elegans ROR receptor tyrosine kinase, CAM-1, non-autonomously inhibits the Wnt pathway.
J. L. Green, T. Inoue, and P. W. Sternberg (2007)
Development
134, 4053-4062
|Abstract »|Full Text »|PDF »
To whom correspondence should be addressed. E-mail: 
