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Type 1 Interferons and the Virus-Host Relationship: A Lesson in Détente
Adolfo García-Sastre1 and
Christine A. Biron2*
The interface between an infectious agent and its host representsthe ultimate battleground for survival: The microbe must securea niche for replication, whereas the host must limit the pathogen'sadvance. Among the host's arsenal of antimicrobial factors,the type 1 interferons (IFNs) induce potent defense mechanismsagainst viruses and are key in the host-virus standoff. Viruseshave evolved multiple tricks to avoid the immediate antiviraleffects of IFNs and, in turn, hosts have adapted use of thisinnate cytokine system to galvanize multiple additional layersof immune defense. The plasticity that exists in these interactionsprovides us with a lesson in détente.
1 Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA. 2 Department of Molecular Microbiology and Immunology, Division of Biology and Medicine, Brown University, Providence, RI 02912, USA.
* To whom correspondence should be addressed. E-mail: Christine_Biron{at}brown.edu
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