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Autophagic Fungal Cell Death Is Necessary for Infection by the Rice Blast Fungus
Claire Veneault-Fourrey,Madhumita Barooah,Martin Egan,Gavin Wakley,Nicholas J. Talbot*
Rice blast is caused by the fungus Magnaporthe grisea, whichelaborates specialized infection cells called appressoria topenetrate the tough outer cuticle of the rice plant Oryza sativa.We found that the formation of an appressorium required, sequentially,the completion of mitosis, nuclear migration, and death of theconidium (fungal spore) from which the infection originated.Genetic intervention during mitosis prevented both appressoriumdevelopment and conidium death. Impairment of autophagy, bythe targeted mutation of the MgATG8 gene, arrested conidialcell death but rendered the fungus nonpathogenic. Thus, theinitiation of rice blast requires autophagic cell death of theconidium.
School of Biosciences, University of Exeter, Washington Singer Laboratories, Perry Road, Exeter EX4 4QG, UK.
* To whom correspondence should be addressed. E-mail: N.J.Talbot{at}exeter.ac.uk
Unexpected Link between Metal Ion Deficiency and Autophagy in Aspergillus fumigatus.
D. L. Richie, K. K. Fuller, J. Fortwendel, M. D. Miley, J. W. McCarthy, M. Feldmesser, J. C. Rhodes, and D. S. Askew (2007)
Eukaryot. Cell
6, 2437-2447
|Abstract »|Full Text »|PDF »
Nuclear Labeling of Coccidioides posadasii with Green Fluorescent Protein.
L. LI, M. SCHMELZ, E. M. KELLNER, J. N. GALGIANI, and M. J. ORBACH (2007)
Ann. N.Y. Acad. Sci.
1111, 198-207
|Abstract »|Full Text »|PDF »
Generation of reactive oxygen species by fungal NADPH oxidases is required for rice blast disease.
M. J. Egan, Z.-Y. Wang, M. A. Jones, N. Smirnoff, and N. J. Talbot (2007)
PNAS
104, 11772-11777
|Abstract »|Full Text »|PDF »
Involvement of a Magnaporthe grisea Serine/Threonine Kinase Gene, MgATG1, in Appressorium Turgor and Pathogenesis.
X.-H. Liu, J.-P. Lu, L. Zhang, B. Dong, H. Min, and F.-C. Lin (2007)
Eukaryot. Cell
6, 997-1005
|Abstract »|Full Text »|PDF »
A Multidrug Resistance Transporter in Magnaporthe Is Required for Host Penetration and for Survival during Oxidative Stress.
C. B. Sun, A. Suresh, Y. Z. Deng, and N. I. Naqvi (2006)
PLANT CELL
18, 3686-3705
|Abstract »|Full Text »|PDF »
Multiple Upstream Signals Converge on the Adaptor Protein Mst50 in Magnaporthe grisea.
G. Park, C. Xue, X. Zhao, Y. Kim, M. Orbach, and J.-R. Xu (2006)
PLANT CELL
18, 2822-2835
|Abstract »|Full Text »|PDF »
Biz1, a Zinc Finger Protein Required for Plant Invasion by Ustilago maydis, Regulates the Levels of a Mitotic Cyclin.
I. Flor-Parra, M. Vranes, J. Kamper, and J. Perez-Martin (2006)
PLANT CELL
18, 2369-2387
|Abstract »|Full Text »|PDF »
