Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
American Association for Cancer Research

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 21 April 2006:
Vol. 312. no. 5772, pp. 436 - 439
DOI: 10.1126/science.1126088
Prev | Table of Contents | Next

Reports

A Plant miRNA Contributes to Antibacterial Resistance by Repressing Auxin Signaling

Lionel Navarro,1,2 Patrice Dunoyer,2 Florence Jay,2 Benedict Arnold,3 Nihal Dharmasiri,4 Mark Estelle,4 Olivier Voinnet,2*{dagger} Jonathan D. G. Jones1*{dagger}

Plants and animals activate defenses after perceiving pathogen-associated molecular patterns (PAMPs) such as bacterial flagellin. In Arabidopsis, perception of flagellin increases resistance to the bacterium Pseudomonas syringae, although the molecular mechanisms involved remain elusive. Here, we show that a flagellin-derived peptide induces a plant microRNA (miRNA) that negatively regulates messenger RNAs for the F-box auxin receptors TIR1, AFB2, and AFB3. Repression of auxin signaling restricts P. syringae growth, implicating auxin in disease susceptibility and miRNA-mediated suppression of auxin signaling in resistance.

1 The Sainsbury Laboratory, John Innes Centre, Colney Lane, Norwich NR4 7UH, UK.
2 Institut de Biologie Molèculaire des Plantes du Centre National de la Recherche Scientifique, 67084 Strasbourg Cedex, France.
3 John Innes Centre, Colney Lane, Norwich NR4 7UH, UK.
4 Department of Biology, Indiana University, Bloomington, IN 47405, USA.

* These authors contributed equally to this work.

{dagger} To whom correspondence should be addressed. E-mail: jonathan.jones{at}sainsbury-laboratory.ac.uk (J.D.G.J.); olivier.voinnet{at}ibmp-ulp.u-strasbg.fr (O.V.)

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Suppression of the MicroRNA Pathway by Bacterial Effector Proteins.
L. Navarro, F. Jay, K. Nomura, S. Y. He, and O. Voinnet (2008)
Science 321, 964-967
   Abstract »    Full Text »    PDF »
Host-Directed Drug Targeting of Factors Hijacked by Pathogens.
A. Schwegmann and F. Brombacher (2008)
Science Signaling 1, re8
   Abstract »    Full Text »    PDF »
Kinetics of Salicylate-Mediated Suppression of Jasmonate Signaling Reveal a Role for Redox Modulation.
A. Koornneef, A. Leon-Reyes, T. Ritsema, A. Verhage, F. C. Den Otter, L.C. Van Loon, and C. M.J. Pieterse (2008)
Plant Physiology 147, 1358-1368
   Abstract »    Full Text »    PDF »
RNA Silencing in Plants: Yesterday, Today, and Tomorrow.
A. Eamens, M.-B. Wang, N. A. Smith, and P. M. Waterhouse (2008)
Plant Physiology 147, 456-468
   Full Text »    PDF »
Altered Disease Development in the eui Mutants and Eui Overexpressors Indicates that Gibberellins Negatively Regulate Rice Basal Disease Resistance.
D.-L. Yang, Q. Li, Y.-W. Deng, Y.-G. Lou, M.-Y. Wang, G.-X. Zhou, Y.-Y. Zhang, and Z.-H. He (2008)
Mol Plant
   Abstract »    Full Text »    PDF »
Microarray-based analysis of stress-regulated microRNAs in Arabidopsis thaliana.
H.-H. Liu, X. Tian, Y.-J. Li, C.-A. Wu, and C.-C. Zheng (2008)
RNA 14, 836-843
   Abstract »    Full Text »    PDF »
Repression of the Auxin Response Pathway Increases Arabidopsis Susceptibility to Necrotrophic Fungi.
F. Llorente, P. Muskett, A. Sanchez-Vallet, G. Lopez, B. Ramos, C. Sanchez-Rodriguez, L. Jorda, J. Parker, and A. Molina (2008)
Mol Plant 1, 496-509
   Abstract »    Full Text »    PDF »
Chemical Ecology Special Feature: Herbivory-induced changes in the small-RNA transcriptome and phytohormone signaling in Nicotiana attenuata.
S. P. Pandey, P. Shahi, K. Gase, and I. T. Baldwin (2008)
PNAS 105, 4559-4564
   Abstract »    Full Text »    PDF »
Tobacco Mosaic Virus Replicase-Auxin/Indole Acetic Acid Protein Interactions: Reprogramming the Auxin Response Pathway To Enhance Virus Infection.
M. S. Padmanabhan, S. R. Kramer, X. Wang, and J. N. Culver (2008)
J. Virol. 82, 2477-2485
   Abstract »    Full Text »    PDF »
Comprehensive Transcriptome Analysis of Auxin Responses in Arabidopsis.
I. A. Paponov, M. Paponov, W. Teale, M. Menges, S. Chakrabortee, J. A.H. Murray, and K. Palme (2008)
Mol Plant 1, 321-337
   Abstract »    Full Text »    PDF »
Cross Talk in Defense Signaling.
A. Koornneef and C. M.J. Pieterse (2008)
Plant Physiology 146, 839-844
   Full Text »    PDF »
Transgenic Expression of a Fungal endo-Polygalacturonase Increases Plant Resistance to Pathogens and Reduces Auxin Sensitivity.
S. Ferrari, R. Galletti, D. Pontiggia, C. Manfredini, V. Lionetti, D. Bellincampi, F. Cervone, and G. De Lorenzo (2008)
Plant Physiology 146, 669-681
   Abstract »    Full Text »    PDF »
Activation of the Indole-3-Acetic Acid-Amido Synthetase GH3-8 Suppresses Expansin Expression and Promotes Salicylate- and Jasmonate-Independent Basal Immunity in Rice.
X. Ding, Y. Cao, L. Huang, J. Zhao, C. Xu, X. Li, and S. Wang (2008)
PLANT CELL 20, 228-240
   Abstract »    Full Text »    PDF »
Pseudomonas syringae type III effector AvrRpt2 alters Arabidopsis thaliana auxin physiology.
Z. Chen, J. L. Agnew, J. D. Cohen, P. He, L. Shan, J. Sheen, and B. N. Kunkel (2007)
PNAS 104, 20131-20136
   Abstract »    Full Text »    PDF »
A novel class of bacteria-induced small RNAs in Arabidopsis.
S. Katiyar-Agarwal, S. Gao, A. Vivian-Smith, and H. Jin (2007)
Genes & Dev. 21, 3123-3134
   Abstract »    Full Text »    PDF »
ARGONAUTE4 Is Required for Resistance to Pseudomonas syringae in Arabidopsis.
A. Agorio and P. Vera (2007)
PLANT CELL 19, 3778-3790
   Abstract »    Full Text »    PDF »
A Nonclassical Arabinogalactan Protein Gene Highly Expressed in Vascular Tissues, AGP31, Is Transcriptionally Repressed by Methyl Jasmonic Acid in Arabidopsis.
C. Liu and M. C. Mehdy (2007)
Plant Physiology 145, 863-874
   Abstract »    Full Text »    PDF »
Dual Regulation Role of GH3.5 in Salicylic Acid and Auxin Signaling during Arabidopsis-Pseudomonas syringae Interaction.
Z. Zhang, Q. Li, Z. Li, P. E. Staswick, M. Wang, Y. Zhu, and Z. He (2007)
Plant Physiology 145, 450-464
   Abstract »    Full Text »    PDF »
Genes misregulated in C. elegans deficient in Dicer, RDE-4, or RDE-1 are enriched for innate immunity genes.
N. C. Welker, J. W. Habig, and B. L. Bass (2007)
RNA 13, 1090-1102
   Abstract »    Full Text »    PDF »
Quantitative Phosphoproteomics of Early Elicitor Signaling in Arabidopsis.
J. J. Benschop, S. Mohammed, M. O'Flaherty, A. J. R. Heck, M. Slijper, and F. L. H. Menke (2007)
Mol. Cell. Proteomics 6, 1198-1214
   Abstract »    Full Text »    PDF »
Regulation of plant innate immunity by three proteins in a complex conserved across the plant and animal kingdoms.
K. Palma, Q. Zhao, Y. T. Cheng, D. Bi, J. Monaghan, W. Cheng, Y. Zhang, and X. Li (2007)
Genes & Dev. 21, 1484-1493
   Abstract »    Full Text »    PDF »
Ubiquitin, Hormones and Biotic Stress in Plants.
K. Dreher and J. Callis (2007)
Ann. Bot. 99, 787-822
   Abstract »    Full Text »    PDF »
DNA demethylation in the Arabidopsis genome.
J. Penterman, D. Zilberman, J. H. Huh, T. Ballinger, S. Henikoff, and R. L. Fischer (2007)
PNAS 104, 6752-6757
   Abstract »    Full Text »    PDF »
GH3-mediated Auxin Homeostasis Links Growth Regulation with Stress Adaptation Response in Arabidopsis.
J.-E. Park, J.-Y. Park, Y.-S. Kim, P. E. Staswick, J. Jeon, J. Yun, S.-Y. Kim, J. Kim, Y.-H. Lee, and C.-M. Park (2007)
J. Biol. Chem. 282, 10036-10046
   Abstract »    Full Text »    PDF »
Cucumber mosaic virus-encoded 2b suppressor inhibits Arabidopsis Argonaute1 cleavage activity to counter plant defense.
X. Zhang, Y.-R. Yuan, Y. Pei, S.-S. Lin, T. Tuschl, D. J. Patel, and N.-H. Chua (2006)
Genes & Dev. 20, 3255-3268
   Abstract »    Full Text »    PDF »
A Family of MicroRNAs Present in Plants and Animals.
M. Arteaga-Vazquez, J. Caballero-Perez, and J.-P. Vielle-Calzada (2006)
PLANT CELL 18, 3355-3369
   Abstract »    Full Text »    PDF »
A pathogen-inducible endogenous siRNA in plant immunity.
S. Katiyar-Agarwal, R. Morgan, D. Dahlbeck, O. Borsani, A. Villegas Jr., J.-K. Zhu, B. J. Staskawicz, and H. Jin (2006)
PNAS 103, 18002-18007
   Abstract »    Full Text »    PDF »
Plant Response to Bacterial Pathogens. Overlap between Innate and Gene-for-Gene Defense Response..
A. K. Grennan (2006)
Plant Physiology 142, 809-811
   Full Text »    PDF »
NF-{kappa}B-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses.
K. D. Taganov, M. P. Boldin, K.-J. Chang, and D. Baltimore (2006)
PNAS 103, 12481-12486
   Abstract »    Full Text »    PDF »
The Arabidopsis SUPPRESSOR OF AUXIN RESISTANCE Proteins Are Nucleoporins with an Important Role in Hormone Signaling and Development.
G. Parry, S. Ward, A. Cernac, S. Dharmasiri, and M. Estelle (2006)
PLANT CELL 18, 1590-1603
   Abstract »    Full Text »    PDF »
Innate Immune Defense Through RNA Interference.
J. H. Fritz, S. E. Girardin, and D. J. Philpott (2006)
Sci. STKE 2006, pe27
   Abstract »    Full Text »    PDF »


ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)