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Science 14 April 2006:
Vol. 312. no. 5771, pp. 212 - 217
DOI: 10.1126/science.1124619
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Review

Mass Spectrometry and Protein Analysis

Bruno Domon1 and Ruedi Aebersold1,2,3

Mass spectrometry is a central analytical technique for protein research and for the study of biomolecules in general. Driven by the need to identify, characterize, and quantify proteins at ever increasing sensitivity and in ever more complex samples, a wide range of new mass spectrometry–based analytical platforms and experimental strategies have emerged. Here we review recent advances in mass spectrometry instrumentation in the context of current and emerging research strategies in protein science.

1 Institute of Molecular Systems Biology, ETH Zurich, CH-8093 Zurich, Switzerland.
2 Faculty of Sciences, University of Zurich, CH-8006 Zurich, Switzerland.
3 Institute for Molecular Systems Biology, Seattle, WA 98103, USA.

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