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Science 7 April 2006:
Vol. 312. no. 5770, p. 55
DOI: 10.1126/science.1115362
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Technical Comments

Response to Comment on "PDK1 Nucleates T Cell Receptor-Induced Signaling Complex for NF-{kappa}B Activation"

Ki-young Lee, Jae-Hyuck Shim, Matthew S. Hayden, Jan-Schulze Luehrmann, Sankar Ghosh*

In their comment, Gruber et al. report constitutive phosphorylation of protein kinase C {theta} at threonine residue 538. However, they fail to note that, consistent with our results, a number of other groups have previously reported inducible phosphorylation of Thr-538 in T cells. Although the physiological relevance of this discrepancy is unclear, substantial differences in experimental conditions and reagents may account for the conflicting observations.

Section of Immunology and Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT 06520, USA.

* To whom correspondence should be addressed. E-mail: Sankar.ghosh{at}yale.edu

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Science. ISSN 0036-8075 (print), 1095-9203 (online)