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ReportsDarwinian Evolution Can Follow Only Very Few Mutational Paths to Fitter Proteins![]()
Five point mutations in a particular ß-lactamase allele jointly increase bacterial resistance to a clinically important antibiotic by a factor of Department of Organismic and Evolutionary Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA.
* To whom correspondence should be addressed. E-mail: dmw{at}post.harvard.edu
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