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Immunological Reversal of Autoimmune Diabetes Without Hematopoietic Replacement of ß Cells
Anish Suri,*Boris Calderon,Thomas J. Esparza,Katherine Frederick,Patrice Bittner,Emil R. Unanue*
Type 1 diabetes mellitus results from the autoimmune destructionof the ß cells of the pancreatic islets of Langerhansand is recapitulated in the nonobese diabetic strain of mice.In an attempt to rescue islet loss, diabetic mice were madenormoglycemic by islet transplantation and immunization withFreund's complete adjuvant along with multiple injections ofallogeneic male splenocytes. This treatment allowed for survivalof transplanted islets and recovery of endogenous ßcell function in a proportion of mice, but with no evidencefor allogeneic splenocyte–derived differentiation of newislet ß cells. Control of the autoimmune disease ata crucial time in diabetogenesis can result in recovery of ßcell function.
Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
* To whom correspondence should be addressed. E-mail: anish{at}pathology.wustl.edu (A.S.); unanue{at}pathbox.wustl.edu (E.R.U.)
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TECHNICAL COMMENTS
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