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Genome-Wide Prediction of C. elegans Genetic Interactions
Weiwei Zhong and
Paul W. Sternberg*
To obtain a global view of functional interactions among genesin a metazoan genome, we computationally integrated interactomedata, gene expression data, phenotype data, and functional annotationdata from three model organismsSaccharomyces cerevisiae,Caenorhabditis elegans, and Drosophila melanogasterandpredicted genome-wide genetic interactions in C. elegans. Theresulting genetic interaction network (consisting of 18,183interactions) provides a framework for system-level understandingof gene functions. We experimentally tested the predicted interactionsfor two human disease-related genes and identified 14 new modifiers.
Howard Hughes Medical Institute and Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA.
* To whom correspondence should be addressed. E-mail: pws{at}caltech.edu
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