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Essential Role of BDNF in the Mesolimbic Dopamine Pathway in Social Defeat Stress
Olivier Berton,1Colleen A. McClung,1Ralph J. DiLeone,*Vaishnav Krishnan,1William Renthal,1Scott J. Russo,1Danielle Graham,1Nadia M. Tsankova,1Carlos A. Bolanos,Maribel Rios,2Lisa M. Monteggia,1David W. Self,1Eric J. Nestler
Mice experiencing repeated aggression develop a long-lastingaversion to social contact, which can be normalized by chronic,but not acute, administration of antidepressant. Using viral-mediated,mesolimbic dopamine pathway–specific knockdown of brain-derivedneurotrophic factor (BDNF), we showed that BDNF is requiredfor the development of this experience-dependent social aversion.Gene profiling in the nucleus accumbens indicates that localknockdown of BDNF obliterates most of the effects of repeatedaggression on gene expression within this circuit, with similareffects being produced by chronic treatment with antidepressant.These results establish an essential role for BDNF in mediatinglong-term neural and behavioral plasticity in response to aversivesocial experiences.
1 Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390–9070, USA. 2 Department of Neuroscience, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA.
* Present address: Department of Psychiatry, Yale University Schoolof Medicine, 34 Park Street, New Haven, CT 06508, USA.
Present address: Department of Psychology and Program in Neuroscience,Florida State University, Tallahassee, FL 32306–1270,USA.
To whom correspondence should be addressed. E-mail: eric.nestler{at}utsouthwestern.edu
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Present address: Department of Psychology and Program in Neuroscience, Florida State University, Tallahassee, FL 32306–1270, USA. 
To whom correspondence should be addressed. E-mail: 
