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Science 27 January 2006:
Vol. 311. no. 5760, pp. 518 - 522
DOI: 10.1126/science.1120847
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Reports

The Cellular Basis of a Corollary Discharge

James F. A. Poulet1,2* and Berthold Hedwig2

How do animals discriminate self-generated from external stimuli during behavior and prevent desensitization of their sensory pathways? A fundamental concept in neuroscience states that neural signals, termed corollary discharges or efference copies, are forwarded from motor to sensory areas. Neurons mediating these signals have proved difficult to identify. We show that a single, multisegmental interneuron is responsible for the pre- and postsynaptic inhibition of auditory neurons in singing crickets (Gryllus bimaculatus). Therefore, this neuron represents a corollary discharge interneuron that provides a neuronal basis for the central control of sensory responses.

1 Laboratory of Sensory Processing, Brain Mind Institute, École Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.
2 Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, UK.

* To whom correspondence should be addressed. E-mail: james.poulet{at}epfl.ch

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Science. ISSN 0036-8075 (print), 1095-9203 (online)