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ReportsLong-Term Transmission of Defective RNA Viruses in Humans and Aedes MosquitoesIn 2001, dengue virus type 1 (DENV-1) populations in humans and mosquitoes from Myanmar acquired a stop-codon mutation in the surface envelope (E) protein gene. Within a year, this stop-codon strain had spread to all individuals sampled. The presence of truncated E protein species within individual viral populations, along with a general relaxation in selective constraint, indicated that the stop-codon strain represents a defective lineage of DENV-1. We propose that such long-term transmission of defective RNA viruses in nature was achieved through complementation by coinfection of host cells with functional viruses.
1 School of Life Sciences, Queensland University of Technology, 2 George Street, Brisbane, 4001, Australia. * To whom correspondence should be addressed. E-mail: ech15{at}psu.edu
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Science. ISSN 0036-8075 (print), 1095-9203 (online)