Related Content
Search Google Scholar for:
More Information
Related Jobs from ScienceCareers
|
|
Science 23 December 2005:
Vol. 310. no. 5756, pp. 1960 - 1963
DOI: 10.1126/science.1121925
|
|
Reports
Protein Synthesis upon Acute Nutrient Restriction Relies on Proteasome Function
Ramunas M. Vabulas* and
F. Ulrich Hartl*
The mechanisms that protect mammalian cells against amino acid deprivation are only partially understood. We found that during an acute decrease in external amino acid supply, before up-regulation of the autophagosomal-lysosomal pathway, efficient translation was ensured by proteasomal protein degradation. Amino acids for the synthesis of new proteins were supplied by the degradation of preexisting proteins, whereas nascent and newly formed polypeptides remained largely protected from proteolysis. Proteasome inhibition during nutrient deprivation caused rapid amino acid depletion and marked impairment of translation. Thus, the proteasome plays a crucial role in cell survival after acute disruption of amino acid supply.
Department of Cellular Biochemistry, Max Planck Institute of Biochemistry, Am Klopferspitz 18, D-82152 Martinsried, Germany.
* To whom correspondence should be addressed: E-mail: vabulas{at}biochem.mpg.de (R.M.V.); uhartl{at}biochem.mpg.de (F.U.H.)
Read the Full Text
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
- Puromycin-Sensitive Aminopeptidase Limits MHC Class I Presentation in Dendritic Cells but Does Not Affect CD8 T Cell Responses during Viral Infections.
- C. F. Towne, I. A. York, J. Neijssen, M. L. Karow, A. J. Murphy, D. M. Valenzuela, G. D. Yancopoulos, J. J. Neefjes, and K. L. Rock (2008)
J. Immunol.
180, 1704-1712
| Abstract »
| Full Text »
| PDF »
- Proteasome activation during cardiac hypertrophy by the chaperone H11 Kinase/Hsp22.
- N. Hedhli, L. Wang, Q. Wang, E. Rashed, Y. Tian, X. Sui, K. Madura, and C. Depre (2008)
Cardiovasc Res
77, 497-505
| Abstract »
| Full Text »
| PDF »
- Unexpected Link between Metal Ion Deficiency and Autophagy in Aspergillus fumigatus.
- D. L. Richie, K. K. Fuller, J. Fortwendel, M. D. Miley, J. W. McCarthy, M. Feldmesser, J. C. Rhodes, and D. S. Askew (2007)
Eukaryot. Cell
6, 2437-2447
| Abstract »
| Full Text »
| PDF »
- Autophagy: process and function.
- N. Mizushima (2007)
Genes & Dev.
21, 2861-2873
| Abstract »
| Full Text »
| PDF »
- In and Out of the ER: Protein Folding, Quality Control, Degradation, and Related Human Diseases.
- D. N. Hebert and M. Molinari (2007)
Physiol Rev
87, 1377-1408
| Abstract »
| Full Text »
| PDF »
- Inhibition of the Ubiquitin-Proteasome System Induces Stress Granule Formation.
- R. Mazroui, S. Di Marco, R. J. Kaufman, and I.-E. Gallouzi (2007)
Mol. Biol. Cell
18, 2603-2618
| Abstract »
| Full Text »
| PDF »
- Acidosis-Sensing Glutamine Pump SNAT2 Determines Amino Acid Levels and Mammalian Target of Rapamycin Signalling to Protein Synthesis in L6 Muscle Cells.
- K. Evans, Z. Nasim, J. Brown, H. Butler, S. Kauser, H. Varoqui, J. D. Erickson, T. P. Herbert, and A. Bevington (2007)
J. Am. Soc. Nephrol.
18, 1426-1436
| Abstract »
| Full Text »
| PDF »
- Tight Linkage between Translation and MHC Class I Peptide Ligand Generation Implies Specialized Antigen Processing for Defective Ribosomal Products.
- S.-B. Qian, E. Reits, J. Neefjes, J. M. Deslich, J. R. Bennink, and J. W. Yewdell (2006)
J. Immunol.
177, 227-233
| Abstract »
| Full Text »
| PDF »
- Amino Acid Starvation Induces the SNAT2 Neutral Amino Acid Transporter by a Mechanism That Involves Eukaryotic Initiation Factor 2{alpha} Phosphorylation and cap-independent Translation.
- F. Gaccioliy, C. C. Huang, C. Wang, E. Bevilacqua, R. Franchi-Gazzola, G. C. Gazzola, O. Bussolati, M. D. Snider, and M. Hatzoglou (2006)
J. Biol. Chem.
281, 17929-17940
| Abstract »
| Full Text »
| PDF »
|
|
