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Science 9 December 2005:
Vol. 310. no. 5754, p. 1641
DOI: 10.1126/science.1118357
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Increase in Activity During Calorie Restriction Requires Sirt1

Danica Chen,1 Andrew D. Steele,1,2 Susan Lindquist,2 Leonard Guarente1*

Sir2 (silent information regulator 2) is a nicotinamide adenine dinucletide-dependent deacetylase required for longevity due to calorie restriction in yeast and Drosophila. In mammals, calorie restriction induces a complex pattern of physiological and behavioral changes. Here we report that the mammalian Sir2 ortholog, Sirt1, is required for the induction of a phenotype by calorie restriction in mice.

1 Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
2 Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA.

* To whom correspondence should be addressed. E-mail: leng{at}mit.edu

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