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Originally published in Science Express on 29 September 2005
Science 28 October 2005:
Vol. 310. no. 5748, pp. 676 - 679
DOI: 10.1126/science.1118391
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Reports

Bats Are Natural Reservoirs of SARS-Like Coronaviruses

Wendong Li,1,2 Zhengli Shi,2* Meng Yu,3 Wuze Ren,2 Craig Smith,4 Jonathan H. Epstein,5 Hanzhong Wang,2 Gary Crameri,3 Zhihong Hu,2 Huajun Zhang,2 Jianhong Zhang,2 Jennifer McEachern,3 Hume Field,4 Peter Daszak,5 Bryan T. Eaton,3 Shuyi Zhang,1,6* Lin-Fa Wang3*

Severe acute respiratory syndrome (SARS) emerged in 2002 to 2003 in southern China. The origin of its etiological agent, the SARS coronavirus (SARS-CoV), remains elusive. Here we report that species of bats are a natural host of coronaviruses closely related to those responsible for the SARS outbreak. These viruses, termed SARS-like coronaviruses (SL-CoVs), display greater genetic variation than SARS-CoV isolated from humans or from civets. The human and civet isolates of SARS-CoV nestle phylogenetically within the spectrum of SL-CoVs, indicating that the virus responsible for the SARS outbreak was a member of this coronavirus group.

1 Institute of Zoology, Chinese Academy of Sciences (CAS), Beijing, China.
2 State Key Laboratory of Virology, Wuhan Institute of Virology, CAS, Wuhan, China.
3 Commonwealth Scientific and Industrial Research Organization (CSIRO) Livestock Industries, Australian Animal Health Laboratory, Geelong, Australia.
4 Department of Primary Industries and Fisheries, Queensland, Australia.
5 The Consortium for Conservation Medicine, New York, USA.
6 Guangzhou Institute of Biomedicine and Health, Guangzhou, China.

* To whom correspondence should be addressed. E-mail: zlshi{at}wh.iov.cn (Z.S.); zhangsy{at}ioz.ac.cn (S.Z.); linfa.wang{at}csiro.au (L.-F.W.)

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