Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
GoGreen Membership

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 28 October 2005:
Vol. 310. no. 5748, pp. 644 - 648
DOI: 10.1126/science.1117679
Prev | Table of Contents | Next

Research Articles

Recurrent Fusion of TMPRSS2 and ETS Transcription Factor Genes in Prostate Cancer

Scott A. Tomlins,1 Daniel R. Rhodes,1,2 Sven Perner,7,9 Saravana M. Dhanasekaran,1 Rohit Mehra,1 Xiao-Wei Sun,7 Sooryanarayana Varambally,1,6 Xuhong Cao,1 Joelle Tchinda,7 Rainer Kuefer,10 Charles Lee,7 James E. Montie,3,5,6 Rajal B. Shah,1,3,5,6 Kenneth J. Pienta,3,4,5,6 Mark A. Rubin,7,8 Arul M. Chinnaiyan1,2,3,5,6*

Recurrent chromosomal rearrangements have not been well characterized in common carcinomas. We used a bioinformatics approach to discover candidate oncogenic chromosomal aberrations on the basis of outlier gene expression. Two ETS transcription factors, ERG and ETV1, were identified as outliers in prostate cancer. We identified recurrent gene fusions of the 5' untranslated region of TMPRSS2 to ERG or ETV1 in prostate cancer tissues with outlier expression. By using fluorescence in situ hybridization, we demonstrated that 23 of 29 prostate cancer samples harbor rearrangements in ERG or ETV1. Cell line experiments suggest that the androgen-responsive promoter elements of TMPRSS2 mediate the overexpression of ETS family members in prostate cancer. These results have implications in the development of carcinomas and the molecular diagnosis and treatment of prostate cancer.

1 Department of Pathology, University of Michigan Medical School, 1301 Catherine Street, Ann Arbor, MI 48109–0602, USA.
2 Bioinformatics Program, University of Michigan Medical School, 1301 Catherine Street, Ann Arbor, MI 48109–0602, USA.
3 Department of Urology, University of Michigan Medical School, 1301 Catherine Street, Ann Arbor, MI 48109–0602, USA.
4 Department of Internal Medicine, University of Michigan Medical School, 1301 Catherine Street, Ann Arbor, MI 48109–0602, USA.
5 Michigan Urology Center, University of Michigan Medical School, 1301 Catherine Street, Ann Arbor, MI 48109–0602, USA.
6 Comprehensive Cancer Center, University of Michigan Medical School, 1301 Catherine Street, Ann Arbor, MI 48109–0602, USA.
7 Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
8 Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
9 Department of Pathology, Harvard Medical School, Boston, MA 02115, USA.
10 Department of Urology, Faculty of Medicine, University of Ulm, Ulm 89075, Germany.

* To whom correspondence should be addressed. E-mail: arul{at}umich.edu

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Microsatellites as EWS/FLI response elements in Ewing's sarcoma.
K. Gangwal, S. Sankar, P. C. Hollenhorst, M. Kinsey, S. C. Haroldsen, A. A. Shah, K. M. Boucher, W. S. Watkins, L. B. Jorde, B. J. Graves, et al. (2008)
PNAS 105, 10149-10154
   Abstract »    Full Text »    PDF »
Steroid Receptor Coactivator-3/AIB1 Promotes Cell Migration and Invasiveness through Focal Adhesion Turnover and Matrix Metalloproteinase Expression.
J. Yan, H. Erdem, R. Li, Y. Cai, G. Ayala, M. Ittmann, L.-y. Yu-Lee, S. Y. Tsai, and M.-J. Tsai (2008)
Cancer Res. 68, 5460-5468
   Abstract »    Full Text »    PDF »
MOST: detecting cancer differential gene expression.
H. Lian (2008)
Biostat. 9, 411-418
   Abstract »    Full Text »    PDF »
Induction of Chromosomal Translocations in Mouse and Human Cells Using Site-Specific Endonucleases.
D. M. Weinstock, E. Brunet, and M. Jasin (2008)
J Natl Cancer Inst Monographs 2008, 20-24
   Abstract »    Full Text »    PDF »
Rapid Testosterone Cycling and Chemotherapy for Prostate Cancer: A Way Forward or Return to the Past?.
M. R. Smith (2008)
J. Clin. Oncol. 26, 2932-2933
   Full Text »    PDF »
Prostate Cancer Stem Cells: A New Target for Therapy.
N. J. Maitland and A. T. Collins (2008)
J. Clin. Oncol. 26, 2862-2870
   Abstract »    Full Text »    PDF »
Genomic outlier profile analysis: mixture models, null hypotheses, and nonparametric estimation.
D. Ghosh and A. M. Chinnaiyan (2008)
Biostat.
   Abstract »    Full Text »    PDF »
Estrogen-Dependent Signaling in a Molecularly Distinct Subclass of Aggressive Prostate Cancer.
S. R. Setlur, K. D. Mertz, Y. Hoshida, F. Demichelis, M. Lupien, S. Perner, A. Sboner, Y. Pawitan, O. Andren, L. A. Johnson, et al. (2008)
J Natl Cancer Inst 100, 815-825
   Abstract »    Full Text »    PDF »
Characterization of TMPRSS2-ERG Fusion High-Grade Prostatic Intraepithelial Neoplasia and Potential Clinical Implications.
J.-M. Mosquera, S. Perner, E. M. Genega, M. Sanda, M. D. Hofer, K. D. Mertz, P. L. Paris, J. Simko, T. A. Bismar, G. Ayala, et al. (2008)
Clin. Cancer Res. 14, 3380-3385
   Abstract »    Full Text »    PDF »
TMPRSS2:ERG Fusion Identifies a Subgroup of Prostate Cancers with a Favorable Prognosis.
O. R. Saramaki, A. E. Harjula, P. M. Martikainen, R. L. Vessella, T. L.J. Tammela, and T. Visakorpi (2008)
Clin. Cancer Res. 14, 3395-3400
   Abstract »    Full Text »    PDF »
Characterization of TMPRSS2-ETS Gene Aberrations in Androgen-Independent Metastatic Prostate Cancer.
R. Mehra, S. A. Tomlins, J. Yu, X. Cao, L. Wang, A. Menon, M. A. Rubin, K. J. Pienta, R. B. Shah, and A. M. Chinnaiyan (2008)
Cancer Res. 68, 3584-3590
   Abstract »    Full Text »    PDF »
Two Unique Novel Prostate-Specific and Androgen-Regulated Fusion Partners of ETV4 in Prostate Cancer.
K. G. Hermans, A. A. Bressers, H. A. van der Korput, N. F. Dits, G. Jenster, and J. Trapman (2008)
Cancer Res. 68, 3094-3098
   Abstract »    Full Text »    PDF »
Functions of Normal and Malignant Prostatic Stem/Progenitor Cells in Tissue Regeneration and Cancer Progression and Novel Targeting Therapies.
M. Mimeault, P. P. Mehta, R. Hauke, and S. K. Batra (2008)
Endocr. Rev. 29, 234-252
   Abstract »    Full Text »    PDF »
Detection of chromosome changes in pathology archives: an application of microwave-assisted fluorescence in situ hybridization to human carcinogenesis studies.
H. Sugimura (2008)
Carcinogenesis 29, 681-687
   Abstract »    Full Text »    PDF »
Identification of Prognostic Biomarkers for Prostate Cancer.
F. Kosari, J. M. A. Munz, C. D. Savci-Heijink, C. Spiro, E. W. Klee, D. M. Kube, L. Tillmans, J. Slezak, R. J. Karnes, J. C. Cheville, et al. (2008)
Clin. Cancer Res. 14, 1734-1743
   Abstract »    Full Text »    PDF »
Inhibition of the Ras-Net (Elk-3) Pathway by a Novel Pyrazole that Affects Microtubules.
C. Wasylyk, H. Zheng, C. Castell, L. Debussche, M.-C. Multon, and B. Wasylyk (2008)
Cancer Res. 68, 1275-1283
   Abstract »    Full Text »    PDF »
Humoral Response Profiling Reveals Pathways to Prostate Cancer Progression.
B. S. Taylor, M. Pal, J. Yu, B. Laxman, S. Kalyana-Sundaram, R. Zhao, A. Menon, J. T. Wei, A. I. Nesvizhskii, D. Ghosh, et al. (2008)
Mol. Cell. Proteomics 7, 600-611
   Abstract »    Full Text »    PDF »
WDR19 Expression is Increased in Prostate Cancer Compared with Normal Cells, but Low-Intensity Expression in Cancers is Associated with Shorter Time to Biochemical Failures and Local Recurrence.
B. Lin, A. G. Utleg, K. Gravdal, J. T. White, O. J. Halvorsen, W. Lu, L. D. True, R. Vessella, P. H. Lange, P. S. Nelson, et al. (2008)
Clin. Cancer Res. 14, 1397-1406
   Abstract »    Full Text »    PDF »
A causal role for ERG in neoplastic transformation of prostate epithelium.
O. Klezovitch, M. Risk, I. Coleman, J. M. Lucas, M. Null, L. D. True, P. S. Nelson, and V. Vasioukhin (2008)
PNAS 105, 2105-2110
   Abstract »    Full Text »    PDF »
A First-Generation Multiplex Biomarker Analysis of Urine for the Early Detection of Prostate Cancer.
B. Laxman, D. S. Morris, J. Yu, J. Siddiqui, J. Cao, R. Mehra, R. J. Lonigro, A. Tsodikov, J. T. Wei, S. A. Tomlins, et al. (2008)
Cancer Res. 68, 645-649
   Abstract »    Full Text »    PDF »
Interplay of Nuclear Factor-{kappa}B and B-myb in the Negative Regulation of Androgen Receptor Expression by Tumor Necrosis Factor {alpha}.
S. Ko, L. Shi, S. Kim, C. S. Song, and B. Chatterjee (2008)
Mol. Endocrinol. 22, 273-286
   Abstract »    Full Text »    PDF »
Starvation Induces Genomic Rearrangements and Starvation-Resilient Phenotypes in Yeast.
S. Coyle and E. Kroll (2008)
Mol. Biol. Evol. 25, 310-318
   Abstract »    Full Text »    PDF »
Oncogenes and Cancer.
C. M. Croce (2008)
N. Engl. J. Med. 358, 502-511
   Full Text »    PDF »
Characterization of TMPRSS2:ETV5 and SLC45A3:ETV5 Gene Fusions in Prostate Cancer.
B. E. Helgeson, S. A. Tomlins, N. Shah, B. Laxman, Q. Cao, J. R. Prensner, X. Cao, N. Singla, J. E. Montie, S. Varambally, et al. (2008)
Cancer Res. 68, 73-80
   Abstract »    Full Text »    PDF »
Glutamine tract length of human androgen receptors affects hormone-dependent and -independent prostate cancer in mice.
M. A. Albertelli, O. A. O'Mahony, M. Brogley, J. Tosoian, M. Steinkamp, S. Daignault, K. Wojno, and D. M. Robins (2008)
Hum. Mol. Genet. 17, 98-110
   Abstract »    Full Text »    PDF »
Detection of TMPRSS2-ERG Translocations in Human Prostate Cancer by Expression Profiling Using GeneChip Human Exon 1.0 ST Arrays.
S. Jhavar, A. Reid, J. Clark, Z. Kote-Jarai, T. Christmas, A. Thompson, C. Woodhouse, C. Ogden, C. Fisher, C. Corbishley, et al. (2008)
J. Mol. Diagn. 10, 50-57
   Abstract »    Full Text »    PDF »
PADGE: analysis of heterogeneous patterns of differential gene expression.
L. Li, A. Chaudhuri, J. Chant, and Z. Tang (2007)
Physiol Genomics 32, 154-159
   Abstract »    Full Text »    PDF »
Androgen Receptor Structural and Functional Elements: Role and Regulation in Prostate Cancer.
S. M. Dehm and D. J. Tindall (2007)
Mol. Endocrinol. 21, 2855-2863
   Abstract »    Full Text »    PDF »
Integrative Microarray Analysis of Pathways Dysregulated in Metastatic Prostate Cancer.
S. R. Setlur, T. E. Royce, A. Sboner, J.-M. Mosquera, F. Demichelis, M. D. Hofer, K. D. Mertz, M. Gerstein, and M. A. Rubin (2007)
Cancer Res. 67, 10296-10303
   Abstract »    Full Text »    PDF »
Androgen Induction of the Androgen Receptor Coactivator Four and a Half LIM Domain Protein-2: Evidence for a Role for Serum Response Factor in Prostate Cancer.
H. V. Heemers, K. M. Regan, S. M. Dehm, and D. J. Tindall (2007)
Cancer Res. 67, 10592-10599
   Abstract »    Full Text »    PDF »
TMPRSS2-ETS fusion prostate cancer: biological and clinical implications.
F. Demichelis and M. A Rubin (2007)
J. Clin. Pathol. 60, 1185-1186
   Full Text »    PDF »
Optimization of primer design for the detection of variable genomic lesions in cancer.
A. Bashir, Y.-T. Liu, B. J. Raphael, D. Carson, and V. Bafna (2007)
Bioinformatics 23, 2807-2815
   Abstract »    Full Text »    PDF »
Extracting three-way gene interactions from microarray data.
J. Zhang, Y. Ji, and L. Zhang (2007)
Bioinformatics 23, 2903-2909
   Abstract »    Full Text »    PDF »
Frequency of the TMPRSS2:ERG gene fusion is increased in moderate to poorly differentiated prostate cancers.
A. B Rajput, M. A Miller, A. De Luca, N. Boyd, S. Leung, A. Hurtado-Coll, L. Fazli, E. C Jones, J. B Palmer, M. E Gleave, et al. (2007)
J. Clin. Pathol. 60, 1238-1243
   Abstract »    Full Text »    PDF »
Genomic Profiling Reveals Alternative Genetic Pathways of Prostate Tumorigenesis.
J. Lapointe, C. Li, C. P. Giacomini, K. Salari, S. Huang, P. Wang, M. Ferrari, T. Hernandez-Boussard, J. D. Brooks, and J. R. Pollack (2007)
Cancer Res. 67, 8504-8510
   Abstract »    Full Text »    PDF »
Heterogeneity of TMPRSS2 Gene Rearrangements in Multifocal Prostate Adenocarcinoma: Molecular Evidence for an Independent Group of Diseases.
R. Mehra, B. Han, S. A. Tomlins, L. Wang, A. Menon, M. J. Wasco, R. Shen, J. E. Montie, A. M. Chinnaiyan, and R. B. Shah (2007)
Cancer Res. 67, 7991-7995
   Abstract »    Full Text »    PDF »
Integrative Analysis of Genomic Aberrations Associated with Prostate Cancer Progression.
J. H. Kim, S. M. Dhanasekaran, R. Mehra, S. A. Tomlins, W. Gu, J. Yu, C. Kumar-Sinha, X. Cao, A. Dash, L. Wang, et al. (2007)
Cancer Res. 67, 8229-8239
   Abstract »    Full Text »    PDF »
Diagnostic Pathology and Laboratory Medicine in the Age of "Omics": A Paper from the 2006 William Beaumont Hospital Symposium on Molecular Pathology.
W. G. Finn (2007)
J. Mol. Diagn. 9, 431-436
   Abstract »    Full Text »    PDF »
Spectral Karyotyping Detects Chromosome Damage in Bronchial Cells of Smokers and Patients with Cancer.
M. Varella-Garcia, L. Chen, R. L. Powell, F. R. Hirsch, T. C. Kennedy, R. Keith, Y. E. Miller, J. D. Mitchell, and W. A. Franklin (2007)
Am. J. Respir. Crit. Care Med. 176, 505-512
   Abstract »    Full Text »    PDF »
Detection of TMPRSS2-ERG Fusion Transcripts and Prostate Cancer Antigen 3 in Urinary Sediments May Improve Diagnosis of Prostate Cancer.
D. Hessels, F. P. Smit, G. W. Verhaegh, J. A. Witjes, E. B. Cornel, and J. A. Schalken (2007)
Clin. Cancer Res. 13, 5103-5108
   Abstract »    Full Text »    PDF »
ETV1 Is a Novel Androgen Receptor-Regulated Gene that Mediates Prostate Cancer Cell Invasion.
C. Cai, C.-L. Hsieh, J. Omwancha, Z. Zheng, S.-Y. Chen, J.-L. Baert, and L. Shemshedini (2007)
Mol. Endocrinol. 21, 1835-1846
   Abstract »    Full Text »    PDF »
High Expression Levels of the ETS-Related Gene, ERG, Predict Adverse Outcome and Improve Molecular Risk-Based Classification of Cytogenetically Normal Acute Myeloid Leukemia: A Cancer and Leukemia Group B Study.
G. Marcucci, K. Maharry, S. P. Whitman, T. Vukosavljevic, P. Paschka, C. Langer, K. Mrozek, C. D. Baldus, A. J. Carroll, B. L. Powell, et al. (2007)
J. Clin. Oncol. 25, 3337-3343
   Abstract »    Full Text »    PDF »
My approach to intraductal lesions of the prostate gland.
M Pickup and T H Van der Kwast (2007)
J. Clin. Pathol. 60, 856-865
   Abstract »    Full Text »    PDF »
A Perspective on DNA Microarrays in Pathology Research and Practice.
J. R. Pollack (2007)
Am. J. Pathol. 171, 375-385
   Abstract »    Full Text »    PDF »
Genome-wide analyses reveal properties of redundant and specific promoter occupancy within the ETS gene family.
P. C. Hollenhorst, A. A. Shah, C. Hopkins, and B. J. Graves (2007)
Genes & Dev. 21, 1882-1894
   Abstract »    Full Text »    PDF »
Protein 4.1B suppresses prostate cancer progression and metastasis.
S. Y. Wong, H. Haack, J. L. Kissil, M. Barry, R. T. Bronson, S. S. Shen, C. A. Whittaker, D. Crowley, and R. O. Hynes (2007)
PNAS 104, 12784-12789
   Abstract »    Full Text »    PDF »
BEX2 Is Overexpressed in a Subset of Primary Breast Cancers and Mediates Nerve Growth Factor/Nuclear Factor-{kappa}B Inhibition of Apoptosis in Breast Cancer Cell Lines.
A. Naderi, A. E. Teschendorff, J. Beigel, M. Cariati, I. O. Ellis, J. D. Brenton, and C. Caldas (2007)
Cancer Res. 67, 6725-6736
   Abstract »    Full Text »    PDF »
c-Jun Has Multiple Enhancing Activities in the Novel Cross Talk between the Androgen Receptor and Ets Variant Gene 1 in Prostate Cancer.
C. Cai, C.-L. Hsieh, and L. Shemshedini (2007)
Mol. Cancer Res. 5, 725-735
   Abstract »    Full Text »    PDF »
Cancer outlier differential gene expression detection.
B. Wu (2007)
Biostat. 8, 566-575
   Abstract »    Full Text »    PDF »
Suppression of androgen receptor-mediated gene expression by a sequence-specific DNA-binding polyamide.
N. G. Nickols and P. B. Dervan (2007)
PNAS 104, 10418-10423
   Abstract »    Full Text »    PDF »
HOOK3-RET: a novel type of RET/PTC rearrangement in papillary thyroid carcinoma.
R. Ciampi, T. J Giordano, K. Wikenheiser-Brokamp, R. J Koenig, and Y. E Nikiforov (2007)
Endocr. Relat. Cancer 14, 445-452
   Abstract »    Full Text »    PDF »
Reduced PDEF Expression Increases Invasion and Expression of Mesenchymal Genes in Prostate Cancer Cells.
X. Gu, L. F. Zerbini, H. H. Otu, M. Bhasin, Q. Yang, M. G. Joseph, F. Grall, T. Onatunde, R. G. Correa, and T. A. Libermann (2007)
Cancer Res. 67, 4219-4226
   Abstract »    Full Text »    PDF »
Altered endocytosis of epidermal growth factor receptor in androgen receptor positive prostate cancer cell lines.
L. Bonaccorsi, D. Nosi, M. Muratori, L. Formigli, G. Forti, and E. Baldi (2007)
J. Mol. Endocrinol. 38, 51-66
   Abstract »    Full Text »    PDF »
Outlier sums for differential gene expression analysis.
R. Tibshirani and T. Hastie (2007)
Biostat. 8, 2-8
   Abstract »    Full Text »    PDF »
Androgen receptor corepressors and prostate cancer.
C. J Burd, L. M Morey, and K. E Knudsen (2006)
Endocr. Relat. Cancer 13, 979-994
   Abstract »    Full Text »    PDF »
COPA--cancer outlier profile analysis.
J. W. MacDonald and D. Ghosh (2006)
Bioinformatics 22, 2950-2951
   Abstract »    Full Text »    PDF »
TMPRSS2:ERG Fusion by Translocation or Interstitial Deletion Is Highly Relevant in Androgen-Dependent Prostate Cancer, But Is Bypassed in Late-Stage Androgen Receptor-Negative Prostate Cancer..
K. G. Hermans, R. van Marion, H. van Dekken, G. Jenster, W. M. van Weerden, and J. Trapman (2006)
Cancer Res. 66, 10658-10663
   Abstract »    Full Text »    PDF »
TMPRSS2 Fusions with Oncogenic ETS Factors in Prostate Cancer Involve Unbalanced Genomic Rearrangements and Are Associated with HDAC1 and Epigenetic Reprogramming.
K. Iljin, M. Wolf, H. Edgren, S. Gupta, S. Kilpinen, R. I. Skotheim, M. Peltola, F. Smit, G. Verhaegh, J. Schalken, et al. (2006)
Cancer Res. 66, 10242-10246
   Abstract »    Full Text »    PDF »
Androgens Modulate Expression of Transcription Intermediary Factor 2, an Androgen Receptor Coactivator whose Expression Level Correlates with Early Biochemical Recurrence in Prostate Cancer.
I. U. Agoulnik, A. Vaid, M. Nakka, M. Alvarado, W. E. Bingman III, H. Erdem, A. Frolov, C. L. Smith, G. E. Ayala, M. M. Ittmann, et al. (2006)
Cancer Res. 66, 10594-10602
   Abstract »    Full Text »    PDF »
NR0B1 Is Required for the Oncogenic Phenotype Mediated by EWS/FLI in Ewing's Sarcoma.
M. Kinsey, R. Smith, and S. L. Lessnick (2006)
Mol. Cancer Res. 4, 851-859
   Abstract »    Full Text »    PDF »
An algorithm for assembly of ordered restriction maps from single DNA molecules.
A. Valouev, D. C. Schwartz, S. Zhou, and M. S. Waterman (2006)
PNAS 103, 15770-15775
   Abstract »    Full Text »    PDF »
A t(1;19)(q10;p10) Mediates the Combined Deletions of 1p and 19q and Predicts a Better Prognosis of Patients with Oligodendroglioma..
R. B. Jenkins, H. Blair, K. V. Ballman, C. Giannini, R. M. Arusell, M. Law, H. Flynn, S. Passe, S. Felten, P. D. Brown, et al. (2006)
Cancer Res. 66, 9852-9861
   Abstract »    Full Text »    PDF »
Androgen receptor as a licensing factor for DNA replication in androgen-sensitive prostate cancer cells.
I. V. Litvinov, D. J. Vander Griend, L. Antony, S. Dalrymple, A. M. De Marzo, C. G. Drake, and J. T. Isaacs (2006)
PNAS 103, 15085-15090
   Abstract »    Full Text »    PDF »
Locus-wide chromatin remodeling and enhanced androgen receptor-mediated transcription in recurrent prostate tumor cells..
L. Jia, H. C. Shen, M. Wantroba, O. Khalid, G. Liang, Q. Wang, E. Gentzschein, J. K. Pinski, F. Z. Stanczyk, P. A. Jones, et al. (2006)
Mol. Cell. Biol. 26, 7331-7341
   Abstract »    Full Text »    PDF »
PACK: Profile Analysis using Clustering and Kurtosis to find molecular classifiers in cancer.
A. E. Teschendorff, A. Naderi, N. L. Barbosa-Morais, and C. Caldas (2006)
Bioinformatics 22, 2269-2275
   Abstract »    Full Text »    PDF »
TMPRSS2:ERG Fusion-Associated Deletions Provide Insight into the Heterogeneity of Prostate Cancer..
S. Perner, F. Demichelis, R. Beroukhim, F. H. Schmidt, J.-M. Mosquera, S. Setlur, J. Tchinda, S. A. Tomlins, M. D. Hofer, K. G. Pienta, et al. (2006)
Cancer Res. 66, 8337-8341
   Abstract »    Full Text »    PDF »
Expression of Variant TMPRSS2/ERG Fusion Messenger RNAs Is Associated with Aggressive Prostate Cancer..
J. Wang, Y. Cai, C. Ren, and M. Ittmann (2006)
Cancer Res. 66, 8347-8351
   Abstract »    Full Text »    PDF »
Fusion between CIC and DUX4 up-regulates PEA3 family genes in Ewing-like sarcomas with t(4;19)(q35;q13) translocation.
M. Kawamura-Saito, Y. Yamazaki, K. Kaneko, N. Kawaguchi, H. Kanda, H. Mukai, T. Gotoh, T. Motoi, M. Fukayama, H. Aburatani, et al. (2006)
Hum. Mol. Genet. 15, 2125-2137
   Abstract »    Full Text »    PDF »
Endoglin expression in the endothelium is regulated by Fli-1, Erg, and Elf-1 acting on the promoter and a -8-kb enhancer.
J. E. Pimanda, W.Y. I. Chan, I. J. Donaldson, M. Bowen, A. R. Green, and B. Gottgens (2006)
Blood 107, 4737-4745
   Abstract »    Full Text »    PDF »
A Systems Approach to Model Metastatic Progression.
B. S. Taylor, S. Varambally, and A. M. Chinnaiyan (2006)
Cancer Res. 66, 5537-5539
   Abstract »    Full Text »    PDF »
Replacing the Mouse Androgen Receptor with Human Alleles Demonstrates Glutamine Tract Length-Dependent Effects on Physiology and Tumorigenesis in Mice.
M. A. Albertelli, A. Scheller, M. Brogley, and D. M. Robins (2006)
Mol. Endocrinol. 20, 1248-1260
   Abstract »    Full Text »    PDF »
Evolution of the Androgen Receptor Pathway during Progression of Prostate Cancer..
P. J.M. Hendriksen, N. F.J. Dits, K. Kokame, A. Veldhoven, W. M. van Weerden, C. H. Bangma, J. Trapman, and G. Jenster (2006)
Cancer Res. 66, 5012-5020
   Abstract »    Full Text »    PDF »
TMPRSS2:ETV4 gene fusions define a third molecular subtype of prostate cancer..
S. A. Tomlins, R. Mehra, D. R. Rhodes, L. R. Smith, D. Roulston, B. E. Helgeson, X. Cao, J. T. Wei, M. A. Rubin, R. B. Shah, et al. (2006)
Cancer Res. 66, 3396-3400
   Abstract »    Full Text »    PDF »


ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)