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Science 28 October 2005:
Vol. 310. no. 5748, pp. 638 - 642
DOI: 10.1126/science.1112160
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Review

Progress in Modeling of Protein Structures and Interactions

Ora Schueler-Furman,1,2 Chu Wang,1 Phil Bradley,1 Kira Misura,1 David Baker1,3*

The prediction of the structures and interactions of biological macromolecules at the atomic level and the design of new structures and interactions are critical tests of our understanding of the interatomic interactions that underlie molecular biology. Equally important, the capability to accurately predict and design macromolecular structures and interactions would streamline the interpretation of genome sequence information and allow the creation of macromolecules with new and useful functions. This review summarizes recent progress in modeling that suggests that we are entering an era in which high-resolution prediction and design will make increasingly important contributions to biology and medicine.

1 Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
2 Department of Molecular Genetics and Biotechnology, Hebrew University, Hadassah Medical School, Jerusalem 91120, Israel.
3 Howard Hughes Medical Institute, Seattle, WA 98195, USA.

* To whom correspondence should be addressed. E-mail: dabaker{at}u.washington.edu

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