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Experience-Driven Plasticity of Visual Cortex Limited by Myelin and Nogo Receptor
Aaron W. McGee,1*Yupeng Yang,2*Quentin S. Fischer,2Nigel W. Daw,2Stephen M. Strittmatter1
Monocular deprivation normally alters ocular dominance in thevisual cortex only during a postnatal critical period (20 to32 days postnatal in mice). We find that mutations in the Nogo-66receptor (NgR) affect cessation of ocular dominance plasticity.In NgR/ mice, plasticity during the critical periodis normal, but it continues abnormally such that ocular dominanceat 45 or 120 days postnatal is subject to the same plasticityas at juvenile ages. Thus, physiological NgR signaling frommyelin-derived Nogo, MAG, and OMgp consolidates the neural circuitryestablished during experience-dependent plasticity. After pathologicaltrauma, similar NgR signaling limits functional recovery andaxonal regeneration.
1 Department of Neurology, Yale University School of Medicine, New Haven, CT 06520, USA. 2 Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, CT 06520, USA.
* These authors contributed equally to this work.
Present address: Department of Neuroscience, Albert EinsteinCollege of Medicine, Bronx, NY 10461, USA.
Present address: Psychiatry and Behavioral Sciences, BaylorCollege of Medicine, Houston, TX 77030, USA.
To whom correspondence should be addressed. E-mail: stephen.strittmatter{at}yale.edu
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