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Science 30 September 2005:
Vol. 309. no. 5744, pp. 2222 - 2226
DOI: 10.1126/science.1114362
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Reports

Experience-Driven Plasticity of Visual Cortex Limited by Myelin and Nogo Receptor

Aaron W. McGee,1* Yupeng Yang,2*{dagger} Quentin S. Fischer,2{ddagger} Nigel W. Daw,2 Stephen M. Strittmatter1§

Monocular deprivation normally alters ocular dominance in the visual cortex only during a postnatal critical period (20 to 32 days postnatal in mice). We find that mutations in the Nogo-66 receptor (NgR) affect cessation of ocular dominance plasticity. In NgR–/– mice, plasticity during the critical period is normal, but it continues abnormally such that ocular dominance at 45 or 120 days postnatal is subject to the same plasticity as at juvenile ages. Thus, physiological NgR signaling from myelin-derived Nogo, MAG, and OMgp consolidates the neural circuitry established during experience-dependent plasticity. After pathological trauma, similar NgR signaling limits functional recovery and axonal regeneration.

1 Department of Neurology, Yale University School of Medicine, New Haven, CT 06520, USA.
2 Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, CT 06520, USA.

* These authors contributed equally to this work.

{dagger} Present address: Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

{ddagger} Present address: Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX 77030, USA.

§ To whom correspondence should be addressed. E-mail: stephen.strittmatter{at}yale.edu

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Science. ISSN 0036-8075 (print), 1095-9203 (online)