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Originally published in Science Express on 28 July 2005
Science 9 September 2005:
Vol. 309. no. 5741, pp. 1739 - 1741
DOI: 10.1126/science.1114580
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Reports

Plague Bacteria Target Immune Cells During Infection

Melanie M. Marketon,1* R. William DePaolo,2* Kristin L. DeBord,1 Bana Jabri,2 Olaf Schneewind1{dagger}

The plague is caused by the bacterium Yersinia pestis. Plague bacteria are thought to inject effector Yop proteins into host cells via the type III pathway. The identity of the host cells targeted for injection during plague infection is unknown. We found, using Yop ß-lactamase hybrids and fluorescent staining of live cells from plague-infected animals, that Y. pestis selected immune cells for injection. In vivo, dendritic cells, macrophages, and neutrophils were injected most frequently, whereas B and T lymphocytes were rarely selected. Thus, it appears that Y. pestis disables these cell populations to annihilate host immune responses during plague.

1 Department of Microbiology, University of Chicago, Chicago, IL 60637, USA.
2 Department of Pathology, University of Chicago, Chicago, IL 60637, USA.

* These authors contributed equally to this work.

{dagger} To whom correspondence should be addressed. E-mail: oschnee{at}bsd.uchicago.edu

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