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Science 2 September 2005:
Vol. 309. no. 5740, pp. 1525 - 1526
DOI: 10.1126/science.1117805
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It's a Small RNA World, After All

Matthew W. Vaughn and Rob Martienssen

Small RNAs (sRNAs) can regulate transcript and protein abundance. Previously, they have been identified using traditional cloning approaches, which has limited how many could be characterized. Now, the Meyers and Green laboratories have used massively parallel signature sequencing technology to find over 1.5 million sRNAs in Arabidopsis thaliana. These new sRNAs reveal a greater-than-expected potential role for sRNAs in gene regulation, preferential expression or usage of sRNAs in flowers, and the prospect of targeted sRNA-mediated regulation of pseudogenes. In addition, new plant microRNAs have been identified, some of which may be unique to Arabidopsis.

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
All possible modes of gene action are observed in a global comparison of gene expression in a maize F1 hybrid and its inbred parents.
R. A. Swanson-Wagner, Y. Jia, R. DeCook, L. A. Borsuk, D. Nettleton, and P. S. Schnable (2006)
PNAS 103, 6805-6810
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Science. ISSN 0036-8075 (print), 1095-9203 (online)