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Science 2 September 2005:
Vol. 309. no. 5740, pp. 1514 - 1518
DOI: 10.1126/science.1111443
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Review

From Birth to Death: The Complex Lives of Eukaryotic mRNAs

Melissa J. Moore

Recent work indicates that the posttranscriptional control of eukaryotic gene expression is much more elaborate and extensive than previously thought, with essentially every step of messenger RNA (mRNA) metabolism being subject to regulation in an mRNA-specific manner. Thus, a comprehensive understanding of eukaryotic gene expression requires an appreciation for how the lives of mRNAs are influenced by a wide array of diverse regulatory mechanisms.

Department of Biochemistry, Howard Hughes Medical Institute, Brandeis University, 415 South Street, Waltham, MA 02454. E-mail: mmoore{at}brandeis.edu

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P. Becht, J. Konig, and M. Feldbrugge (2006)
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Genome-wide analysis of mRNAs bound to the histone stem-loop binding protein.
W.H. D. Townley-Tilson, S. A. Pendergrass, W. F. Marzluff, and M. L. Whitfield (2006)
RNA 12, 1853-1867
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R. Pullmann Jr., K. Abdelmohsen, A. Lal, J. L. Martindale, R. D. Ladner, and M. Gorospe (2006)
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Myogenic gene expression at rest and after a bout of resistance exercise in young (18-30 yr) and old (80-89 yr) women.
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