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Contact-Dependent Inhibition of Growth in Escherichia coli
Stephanie K. Aoki,Rupinderjit Pamma,Aaron D. Hernday,Jessica E. Bickham,Bruce A. Braaten,David A. Low*
Bacteria have developed mechanisms to communicate and competewith each other for limited environmental resources. We foundthat certain Escherichia coli, including uropathogenic strains,contained a bacterial growth-inhibition system that uses directcell-to-cell contact. Inhibition was conditional, dependentupon the growth state of the inhibitory cell and the pili expressionstate of the target cell. Both a large cell-surface proteindesignated Contact-dependent inhibitor A (CdiA) and two-partnersecretion family member CdiB were required for growth inhibition.The CdiAB system may function to regulate the growth of specificcells within a differentiated bacterial population.
Molecular, Cellular, and Developmental Biology, University of California–Santa Barbara (UCSB), Santa Barbara, CA 93106, USA.
* To whom correspondence should be addressed. E-mail: low{at}lifesci.ucsb.edu
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J. Bacteriol.
190, 4027-4037
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Appl. Envir. Microbiol.
73, 7934-7946
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189, 3452-3461
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189, 2759-2768
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Epigenetic Gene Regulation in the Bacterial World.
How to become a uropathogen: Comparative genomic analysis of extraintestinal pathogenic Escherichia coli strains.
E. Brzuszkiewicz, H. Bruggemann, H. Liesegang, M. Emmerth, T. Olschlager, G. Nagy, K. Albermann, C. Wagner, C. Buchrieser, L. Emody, et al. (2006)
PNAS
103, 12879-12884
|Abstract »|Full Text »|PDF »
Broad-spectrum biofilm inhibition by a secreted bacterial polysaccharide.
J. Valle, S. Da Re, N. Henry, T. Fontaine, D. Balestrino, P. Latour-Lambert, and J.-M. Ghigo (2006)
PNAS
103, 12558-12563
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